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Cbl-b-IN-3

Cbl-b-IN-3
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Purity:98.99%
ee:100%

Cbl-b-IN-3

Catalog No. T63790Cas No. 2573775-59-2
Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ζ through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb-/ -T cell activation.
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Pack SizePriceAvailabilityQuantity
1 mg$383In Stock
5 mg$915In Stock
10 mg$1,250In Stock
25 mg$1,850In Stock
50 mg$2,480In Stock
100 mg$3,370In Stock
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Product Introduction

Bioactivity
Description
Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ζ through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb-/ -T cell activation.
In vitro
Cbl-b-IN-3, augments the secretion of IL-2 by T-cells when stimulated with either an anti-CD3 antibody alone or in combination with an anti-CD28 antibody [1].
Chemical Properties
Molecular Weight537.62
FormulaC30H34F3N5O
Cas No.2573775-59-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: Slightly soluble

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