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Cergutuzumab amunaleukin
Catalog No. T76944Cas No. 1509916-03-3
Alias RO 6895882, RG 7813, CEA-IL2v
Cergutuzumab amunaleukin (CEA-IL2v) is a CEA-targeted IL-2 variant immunocytokine for combination cancer immunotherapy with immunostimulatory and anti-tumor activities for the study of solid cancers.
Cergutuzumab amunaleukin
Cergutuzumab amunaleukin
Catalog No. T76944Alias RO 6895882, RG 7813, CEA-IL2vCas No. 1509916-03-3
Cergutuzumab amunaleukin (CEA-IL2v) is a CEA-targeted IL-2 variant immunocytokine for combination cancer immunotherapy with immunostimulatory and anti-tumor activities for the study of solid cancers.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $428 | In Stock | |
| 5 mg | $1,090 | In Stock | |
| 10 mg | $1,780 | In Stock | |
| 25 mg | $2,630 | In Stock | |
| 50 mg | $3,570 | In Stock |
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CitedSelect Batch
Concentration:5.26 mg/mL
Purity:99.7% (SEC-HPLC)
Contact us for more batch information
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Product Introduction
Bioactivity
Chemical Properties
| Description | Cergutuzumab amunaleukin (CEA-IL2v) is a CEA-targeted IL-2 variant immunocytokine for combination cancer immunotherapy with immunostimulatory and anti-tumor activities for the study of solid cancers. |
| In vitro | Cergutuzumab amunaleukin contains a single IL-2 variant (IL2V) part. The CD25 is abolished and blends to the high-end C-terminal. By removing the combination of CD25, Cergutuzumab amunaleukin can avoid priority activation of regulating T cells relative to immune effect cells. [1] Cergutuzumab amunaleukin activated the NK cells and converted into a killing of CEA-positive colon cancer cell line LS180, accompanied by the increase in the release of granase B, IFNγ, and RANTES, and the upward increase of CD25 and CD69 NK cells. [1] |
| In vivo | Among the tumor-free mice treated with 0.5 and 2 mg/kg Cergutuzumab amunaleukin (i.v.; Once) the strong amplification of CD8+ T and NK cells after treatment. [1] |
| Alias | RO 6895882, RG 7813, CEA-IL2v |
| Molecular Weight | 162.05 kDa |
| Cas No. | 1509916-03-3 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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