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Chiglitazar

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Catalog No. T14948Cas No. 743438-45-1

Chiglitazar is a dual agonist of PPARα/γ (EC50s: 1.2, 0.08, and 1.7 μM for PPARα, PPARγ, and PPARδ).

Chiglitazar

Chiglitazar

😃Good
Catalog No. T14948Cas No. 743438-45-1
Chiglitazar is a dual agonist of PPARα/γ (EC50s: 1.2, 0.08, and 1.7 μM for PPARα, PPARγ, and PPARδ).
Pack SizePriceAvailabilityQuantity
25 mg906 €6-8 weeks
50 mg1.178 €6-8 weeks
100 mg1.890 €6-8 weeks
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Product Introduction

Bioactivity
Description
Chiglitazar is a dual agonist of PPARα/γ (EC50s: 1.2, 0.08, and 1.7 μM for PPARα, PPARγ, and PPARδ).
Targets&IC50
PPARα:1.8 μM (EC50), PPARδ:1.7 μM (EC50), PPARγ:0.08 μM (EC50)
In vitro
Chiglitazar shows weaker PPARγ activating activity than rosiglitazone, but stronger than pioglitazone. In terms of PPARα activation, Chiglitazar shows a more potent activity than rosiglitazone, pioglitazone, or WY14643 which is a selective PPARα agonist [1].
In vivo
Plasma glucose levels in the MSG rats treated with Chiglitazar or rosiglitazone are significantly reduced compared with the control group treated with the vehicle, after insulin injection. Fasting PI levels are lower in animals treated with Chiglitazar and rosiglitazone than control. Chiglitazar ameliorates the HOMA indices. For IPGTT, at the 30?min after glucose loading, the glucose values in the 5 and 10?mg/kg Chiglitazar and rosiglitazone-treatment groups are significantly lower than those in the vehicle treatment group [1].
Chemical Properties
Molecular Weight572.62
FormulaC36H29FN2O4
Cas No.743438-45-1
Relative Density.1.25 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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