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CJ-42794

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COA HPLC HNMR

CJ-42794

Catalog No. T14975Cas No. 847728-01-2

CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3) (IC50 : 8.5 (pKi )).

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Pack Size	Price	Availability
5 mg	$32	In Stock
10 mg	$50	In Stock
25 mg	$98	In Stock
1 mL x 10 mM (in DMSO)	$51	In Stock

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Product Introduction

Bioactivity

Description	CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3) (IC50 : 8.5 (pKi )).
In vitro	CJ-042794 competitively inhibits PGE2-evoked elevations of intracellular cAMP levels in HEK293 cells overexpressing human EP4receptor (mean pA2: 8.6). CJ-042794 reverses the inhibitory effects of PGE2 on LPS-induced TNFα production in a concentration-dependent manner [1].
In vivo	CJ-42794 significantly delays ulcer healing in rats and mice and these responses were both attenuated by coadministration of CJ-42794 [2].
Alias	CJ-042794

Chemical Properties

Molecular Weight	413.83
Formula	C22H17ClFNO4
Cas No.	847728-01-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 28 mg/mL (67.66 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4165 mL	12.0823 mL	24.1645 mL	120.8226 mL
5 mM	0.4833 mL	2.4165 mL	4.8329 mL	24.1645 mL
10 mM	0.2416 mL	1.2082 mL	2.4165 mL	12.0823 mL
20 mM	0.1208 mL	0.6041 mL	1.2082 mL	6.0411 mL
50 mM	0.0483 mL	0.2416 mL	0.4833 mL	2.4165 mL

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Keywords

prostaglandin E2CJ42794tumor necrosis factor αCJ042794cAMPgastric ulcersNR3C3inhibitCJ 42794human whole bloodCJ 042794Progesterone ReceptorInhibitorCJ-42794