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Clopidogrel Carboxylic Acid (hydrochloride)

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Catalog No. T36112Cas No. 144750-42-5

Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity. An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite. Clopidogrel carboxylic acid is a major inactive metabolite of clopidogrel. Most (85%) of circulating clopidogrel is hydrolyzed by esterases to this carboxylic acid form. This inactive metabolite can be used as a reference standard for quantitative analysis of clopidogrel metabolism.

Clopidogrel Carboxylic Acid (hydrochloride)

Clopidogrel Carboxylic Acid (hydrochloride)

🥰Excellent
Catalog No. T36112Cas No. 144750-42-5
Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity. An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite. Clopidogrel carboxylic acid is a major inactive metabolite of clopidogrel. Most (85%) of circulating clopidogrel is hydrolyzed by esterases to this carboxylic acid form. This inactive metabolite can be used as a reference standard for quantitative analysis of clopidogrel metabolism.
Pack SizePriceAvailabilityQuantity
1 mg$30 In Stock
5 mg$60 In Stock
10 mg$90 In Stock
25 mg$155 In Stock
50 mg$230 In Stock
100 mg$360 In Stock
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Product Introduction

Bioactivity
Description
Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity. An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite. Clopidogrel carboxylic acid is a major inactive metabolite of clopidogrel. Most (85%) of circulating clopidogrel is hydrolyzed by esterases to this carboxylic acid form. This inactive metabolite can be used as a reference standard for quantitative analysis of clopidogrel metabolism.
Chemical Properties
Molecular Weight344.26
FormulaC15H15Cl2NO2S
Cas No.144750-42-5
Relative Density.no data available
Storage & Solubility Information
Storagestore under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
PBS (pH 7.2): 10 mg/mL (29.05 mM), Sonication is recommended.
Ethanol: 50 mg/mL (145.24 mM), Sonication is recommended.
DMSO: 50 mg/mL (145.24 mM), Sonication is recommended.
DMF: 50 mg/mL (145.24 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/Ethanol/DMSO/DMF
1mg5mg10mg50mg
1 mM2.9048 mL14.5239 mL29.0478 mL145.2391 mL
5 mM0.5810 mL2.9048 mL5.8096 mL29.0478 mL
10 mM0.2905 mL1.4524 mL2.9048 mL14.5239 mL
20 mM0.1452 mL0.7262 mL1.4524 mL7.2620 mL
Ethanol/DMSO/DMF
1mg5mg10mg50mg
50 mM0.0581 mL0.2905 mL0.5810 mL2.9048 mL
100 mM0.0290 mL0.1452 mL0.2905 mL1.4524 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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