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Compound 3344 hydrochloride
🥰Excellent
Catalog No. T9184L
Alias Compound 3344 hydrochloride (2368246-78-8 free base)
Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nM.
Compound 3344 hydrochloride
🥰Excellent
Purity: 99.23%
Catalog No. T9184LAlias Compound 3344 hydrochloride (2368246-78-8 free base)
Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $146 | In Stock | |
| 5 mg | $298 | In Stock | |
| 10 mg | $448 | In Stock | |
| 25 mg | $739 | In Stock | |
| 50 mg | $987 | In Stock | |
| 100 mg | $1,380 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $353 | In Stock |
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Purity:99.23%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nM. |
| In vitro | In vitro competition studies of 3344 hydrochloride binding to KRAS-G12V in waterLOGSY NMR show the anti-RAS scFv inhibits 3344 hydrochloride binding to KRAS. In view of the in vitro inhibition by the anti-RAS scFv of 3344 hydrochloride binding to RASand because the iDAb RAS interferes with BRET signal in cells, 3344 hydrochloride was used for validation of the BRET2 toolbox for RAS-effector PPI inhibitors. |
| Alias | Compound 3344 hydrochloride (2368246-78-8 free base) |
| Molecular Weight | 426.94 |
| Formula | C24H27ClN2O3 |
| Smiles | COC1=CC(C2=C3OCCOC3=CC=C2)=CC=C1NC4=CC=CC(CN(C)C)=C4.[H]Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/ml (140.53 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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