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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $38 | In Stock | |
5 mg | $82 | In Stock | |
10 mg | $132 | In Stock | |
25 mg | $265 | In Stock | |
50 mg | $423 | In Stock | |
100 mg | $628 | In Stock | |
500 mg | $1,350 | In Stock | |
1 mL x 10 mM (in DMSO) | $127 | In Stock |
Description | Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2). Compound C108 can be used in studies about breast tumors and esophageal squamous cell carcinoma. |
In vitro | In BT474 cells, Compound C108 (1 μM) shows anti-tumor activity[1]. In G3BP2 overexpressing KYSE410 cells and LINC01554 transfected KYSE30 cells, Compound C108 (4 μM) reduces the protein expression of G3BP2 and attenuates ESCC cell metastasis, migration and invasion[2]. |
In vivo | In a mouse xenograft model of breast cancer, compound C108 (1 μM) reduces the proportion of tumor-initiating cells approximately 10-fold[1]. |
Molecular Weight | 270.28 |
Formula | C15H14N2O3 |
Cas No. | 15533-09-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMF:PBS(pH 7.2)(1:6): 0.14 mg/mL DMF: 1 mg/mL DMSO: 22.5 mg/mL (83.2 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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