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CST626
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Catalog No. T78947
CST626 (Compound 9), a pan-IAP degrader PROTAC, effectively degrades XIAP, cIAP1, and cIAP2 in MM.1S cells with DC50 values of 0.7, 2.4, and 6.2 nM, respectively [1].
CST626
CST626
😃Good
Purity: 95.87%
Catalog No. T78947
CST626 (Compound 9), a pan-IAP degrader PROTAC, effectively degrades XIAP, cIAP1, and cIAP2 in MM.1S cells with DC50 values of 0.7, 2.4, and 6.2 nM, respectively [1].
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Product Introduction
Bioactivity
Chemical Properties
| Description | CST626 (Compound 9), a pan-IAP degrader PROTAC, effectively degrades XIAP, cIAP1, and cIAP2 in MM.1S cells with DC50 values of 0.7, 2.4, and 6.2 nM, respectively [1]. |
| In vitro | CST626 (Compound 9) induces the degradation of cIAP1, cIAP2, and XIAP in a dose-dependent manner with DC50 values of 2.4 nM, 6.2 nM, and 0.7 nM, respectively [1]. CST626 (0-10 μM; 96 h) significantly inhibits the viability of cancer cells [1]. |
| Molecular Weight | 1103.42 |
| Formula | C61H82N8O9S |
Storage & Solubility Information
| Storage | store at low temperature | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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