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Cyclic-di-GMP disodium

Cyclic-di-GMP disodium
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Purity:99.93%
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Cyclic-di-GMP disodium

Catalog No. T36983Cas No. 2222132-40-1
Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, and cell cycle progression.Cyclic-di-GMP disodium displays antiproliferative activity against cancer cells, inducing elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research cancer.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$139In Stock
5 mg$372In Stock
10 mg$513In Stock
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Product Introduction

Bioactivity
Description
Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, and cell cycle progression.Cyclic-di-GMP disodium displays antiproliferative activity against cancer cells, inducing elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research cancer.
In vitro
Cyclic-di-GMP disodium (0.5-50 μM; 5 days) demonstrates inhibition of human colon cancer cell proliferation.[1]
Cyclic-di-GMP disodium (0.5-50 μM; 5 days) induces a targeted increase in CD4 expression within Jurkat cells and triggers S-phase cell cycle arrest in the same cells.[2]
In vivo
Cyclic-di-GMP disodium (100 μg/per; i.v.; two sequential vaccinations 9 days apart) augments TriVax-induced immune responses against melanoma in mice and further amplifies the anti-tumor effects of TriVax.[3]
AliasCyclic diguanylate, 5GP-5GP disodium, 3',5'-Cyclic diguanylic acid, Cyclic di-GMP (sodium salt), cyclic diguanylate disodium, c-di-GMP, c-di-GMP disodium
Chemical Properties
Molecular Weight736.39
FormulaC20H24N10Na2O14P2
Cas No.2222132-40-1
Storage & Solubility Information
Storagestore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 144.0 mg/mL (196.1 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.3580 mL6.7899 mL13.5798 mL67.8988 mL
5 mM0.2716 mL1.3580 mL2.7160 mL13.5798 mL
10 mM0.1358 mL0.6790 mL1.3580 mL6.7899 mL
20 mM0.0679 mL0.3395 mL0.6790 mL3.3949 mL
50 mM0.0272 mL0.1358 mL0.2716 mL1.3580 mL
100 mM0.0136 mL0.0679 mL0.1358 mL0.6790 mL

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