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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $139 | In Stock | |
5 mg | $372 | In Stock | |
10 mg | $513 | In Stock |
Description | Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, and cell cycle progression.Cyclic-di-GMP disodium displays antiproliferative activity against cancer cells, inducing elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research cancer. |
In vitro | Cyclic-di-GMP disodium (0.5-50 μM; 5 days) demonstrates inhibition of human colon cancer cell proliferation.[1] Cyclic-di-GMP disodium (0.5-50 μM; 5 days) induces a targeted increase in CD4 expression within Jurkat cells and triggers S-phase cell cycle arrest in the same cells.[2] |
In vivo | Cyclic-di-GMP disodium (100 μg/per; i.v.; two sequential vaccinations 9 days apart) augments TriVax-induced immune responses against melanoma in mice and further amplifies the anti-tumor effects of TriVax.[3] |
Alias | Cyclic diguanylate, 5GP-5GP disodium, 3',5'-Cyclic diguanylic acid, Cyclic di-GMP (sodium salt), cyclic diguanylate disodium, c-di-GMP, c-di-GMP disodium |
Molecular Weight | 736.39 |
Formula | C20H24N10Na2O14P2 |
Cas No. | 2222132-40-1 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 144.0 mg/mL (196.1 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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