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Cyclic-di-GMP disodium

Name: Cyclic-di-GMP disodium
Brand: TargetMol
SKU: T36983
Price: 132 EUR
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T36983Cas No. 2222132-40-1

Alias cyclic diguanylate disodium, Cyclic di-GMP (sodium salt), c-di-GMP disodium, 5GP-5GP disodium, 3',5'-Cyclic diguanylic acid

Cyclic-di-GMP disodium (5GP-5GP disodium) is a STING agonist and a second messenger in bacteria. It is involved in a variety of processes in prokaryotes, including biofilm formation, motility, and cell cycle progression. Cyclic-di-GMP disodium (5GP-5GP disodium) exhibits antiproliferative activity against cancer cells, inducing increased CD4 receptor expression and cell cycle arrest, and is a novel therapeutic agent that can be developed to prevent or treat cancer.

Cyclic-di-GMP disodium

🥰Excellent

Purity: 99.93%

Catalog No. T36983Alias cyclic diguanylate disodium, Cyclic di-GMP (sodium salt), c-di-GMP disodium, 5GP-5GP disodium, 3',5'-Cyclic diguanylic acidCas No. 2222132-40-1

Pack Size	Price	Availability
1 mg	132 €	In Stock
5 mg	353 €	In Stock
10 mg	487 €	In Stock

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Purity:99.93%

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COA HNMR HPLC

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Product Introduction

Bioactivity

Description	Cyclic-di-GMP disodium (5GP-5GP disodium) is a STING agonist and a second messenger in bacteria. It is involved in a variety of processes in prokaryotes, including biofilm formation, motility, and cell cycle progression. Cyclic-di-GMP disodium (5GP-5GP disodium) exhibits antiproliferative activity against cancer cells, inducing increased CD4 receptor expression and cell cycle arrest, and is a novel therapeutic agent that can be developed to prevent or treat cancer.
In vitro	METHODS: H508 cells were treated with cyclized-di-GMP disodium (5GP-5GP disodium) (0.5-50 μM, 5 days) and cell proliferation was measured using a validated sulforhodamine B (SRB) colorimetric assay. RESULTS The highest concentration (50 μM) of c-di-GMP reduced H508 cell proliferation by approximately 15%. [1] METHODS: Cyclic-di-GMP disodium (5GP-5GP disodium) (50, 100μM) was used to treat Jur kat cells, and the CD4 level in the cells was observed. RESULTS Cyclic-di-GMP disodium (5GP-5GP disodium) at a concentration of 50μM can induce a 6.3-fold increase in CD4 levels in Jur kat cells, and this was dose-dependent. Cyclic-di-GMP disodium (5GP-5GP disodium) at a concentration of 100μM treated Jur kat cells, resulting in a 9.1-fold increase in CD4 compared to the control group. [2]
In vivo	METHODS: Cyclic-di-GMP disodium (5GP-5GP disodium) (100 μg, intravenous injection) was used in mice in the primary and booster phases to verify whether it would further enhance the immune response to TriVax. RESULTS Cyclic-di-GMP disodium (5GP-5GP disodium) can effectively enhance the magnitude of the immune response produced by TriVax. [3]
Alias	cyclic diguanylate disodium, Cyclic di-GMP (sodium salt), c-di-GMP disodium, 5GP-5GP disodium, 3',5'-Cyclic diguanylic acid

Chemical Properties

Molecular Weight	734.38
Formula	C₂₀H₂₂N₁₀Na₂O₁₄P₂
Cas No.	2222132-40-1
Smiles	O=C1C2=C(NC(N)=N1)N([C@H]3[C@@H]([C@@]4([H])[C@](COP([O-])(O[C@]5([H])[C@@](O[C@@H](N6C7=C(C(N=C(N7)N)=O)N=C6)[C@@H]5O)([H])COP([O-])(O4)=O)=O)([H])O3)O)C=N2.[Na+].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 144.0 mg/mL (196.1 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.3617 mL	6.8085 mL	13.6169 mL	68.0846 mL
5 mM	0.2723 mL	1.3617 mL	2.7234 mL	13.6169 mL
10 mM	0.1362 mL	0.6808 mL	1.3617 mL	6.8085 mL
20 mM	0.0681 mL	0.3404 mL	0.6808 mL	3.4042 mL
50 mM	0.0272 mL	0.1362 mL	0.2723 mL	1.3617 mL
100 mM	0.0136 mL	0.0681 mL	0.1362 mL	0.6808 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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