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dBRD9 HCl
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Catalog No. T31221LCas No. 2341840-98-8
Alias dBRD9 HCl(2170679-45-3 Free base)
dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . dBRD9 HCl is a potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). dBRD9 HCl does not degrade BRD4 or BRD7 at concentrations up to 5 μM. dBRD9 HCl displays antiproliferative effects in human AML cell lines.
dBRD9 HCl
😃Good
Purity: 99.37%
Catalog No. T31221LAlias dBRD9 HCl(2170679-45-3 Free base)Cas No. 2341840-98-8
dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . dBRD9 HCl is a potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). dBRD9 HCl does not degrade BRD4 or BRD7 at concentrations up to 5 μM. dBRD9 HCl displays antiproliferative effects in human AML cell lines.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $197 | In Stock | |
| 25 mg | $1,328 | Backorder | |
| 50 mg | $1,851 | Backorder | |
| 100 mg | $2,778 | Backorder |
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Purity:99.37%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . dBRD9 HCl is a potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). dBRD9 HCl does not degrade BRD4 or BRD7 at concentrations up to 5 μM. dBRD9 HCl displays antiproliferative effects in human AML cell lines. |
| Targets&IC50 | BRD9:56.6 nM |
| In vitro | dBRD9 (0.5-5000 nM; 4 h) reduces the expression of BRD9 in MOLM-13 cells in a concentration dependent manner with no significant effect on the expression of actin, BRD4, and BRD7. dBRD9 (100 nM; 2 hours) exhibits selectivity towards BRD9 in MOLM-13 cells. dBRD9 (7 days) exhibits anti-proliferative effects on EOL-1 and MOML-13 cell lines [1]. |
| Alias | dBRD9 HCl(2170679-45-3 Free base) |
| Molecular Weight | 856.75 |
| Formula | C40H47Cl2N7O10 |
| Cas No. | 2341840-98-8 |
| Smiles | O=C1C2=C(C(C3=CC(OC)=C(CN(CC(NCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C)C(OC)=C3)=CN1C)C=CN=C2.Cl.Cl |
Storage & Solubility Information
| Storage | store at low temperature | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 15.4 mg/mL (18.0 mM) DMSO: 38.5 mg/mL (45.0 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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