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dBRD9

🥰Excellent
Catalog No. T31221Cas No. 2170679-45-3
Alias dBRD-9, dBRD 9

dBRD9 is a PROTAC. dBRD9 is a double-acting molecule, partially containing Bromodomain-containing protein 9 (BRD9), ligand that recruits the cereblon E3 ubiquitin ligase. Ligand that recruits the cereblon E3 ubiquitin ligase. dBRD9 can inhibit the degradation of BRD9 in MOLM-13 cells, and the IC50 is 104 nM.

dBRD9

dBRD9

🥰Excellent
Purity: 99.81%
Catalog No. T31221Alias dBRD-9, dBRD 9Cas No. 2170679-45-3
dBRD9 is a PROTAC. dBRD9 is a double-acting molecule, partially containing Bromodomain-containing protein 9 (BRD9), ligand that recruits the cereblon E3 ubiquitin ligase. Ligand that recruits the cereblon E3 ubiquitin ligase. dBRD9 can inhibit the degradation of BRD9 in MOLM-13 cells, and the IC50 is 104 nM.
Pack SizePriceAvailabilityQuantity
1 mg$131In Stock
5 mg$328In Stock
10 mg$528In Stock
25 mg$920In Stock
50 mg$1,390In Stock
100 mg$1,930In Stock
1 mL x 10 mM (in DMSO)$457In Stock
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Purity:99.81%
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Product Introduction

Bioactivity
Description
dBRD9 is a PROTAC. dBRD9 is a double-acting molecule, partially containing Bromodomain-containing protein 9 (BRD9), ligand that recruits the cereblon E3 ubiquitin ligase. Ligand that recruits the cereblon E3 ubiquitin ligase. dBRD9 can inhibit the degradation of BRD9 in MOLM-13 cells, and the IC50 is 104 nM.
Targets&IC50
BRD9 (MOLM-13 cells):104 nM
In vitro
dBRD9 has prompt rapid BRD9 degradation over a broad range of concentrations. The degraded BRD9 showed significantly enhanced efficacy(10-to-100-fold). These findings reveal the tractability of non-BET bromodomain-containing proteins to chemical degradation and highlight lead compound dBRD9 as a tool for the study of BRD9[1].
In vivo
The final concentration of dBRD9 of 0.3 nM was mixed in silk fibroin hydrogel and injected into mice. It was found that BRD9 degradant alleviated ZOL-related ONJ. The ONJ-dBRD9 group is filled with well-organized newly formed trabecular bone, with 80% reduced incidence rate of osteonecrosis and periosteal reaction compared with the ONJ-control group[1].
AliasdBRD-9, dBRD 9
Chemical Properties
Molecular Weight783.83
FormulaC40H45N7O10
Cas No.2170679-45-3
SmilesO=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCNC(CN(CC4=C(OC)C=C(C=C4OC)C=5C=6C(C(=O)N(C)C5)=CN=CC6)C)=O
Relative Density.1.357 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90.0 mg/mL (114.8 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.2758 mL6.3789 mL12.7579 mL63.7893 mL
5 mM0.2552 mL1.2758 mL2.5516 mL12.7579 mL
10 mM0.1276 mL0.6379 mL1.2758 mL6.3789 mL
20 mM0.0638 mL0.3189 mL0.6379 mL3.1895 mL
50 mM0.0255 mL0.1276 mL0.2552 mL1.2758 mL
100 mM0.0128 mL0.0638 mL0.1276 mL0.6379 mL

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