Shopping Cart
- Remove All
Your shopping cart is currently empty
Diaplasinin
🥰Excellent
Catalog No. T25915Cas No. 481631-45-2
Alias PAI-749, PAI749
Diaplasinin (PAI-749) is a highly efficient inhibitor of plasminogen activator inhibitor-1 (PAI-1) with antithrombotic activity. It can be used in cardiovascular disease research.
Diaplasinin
🥰Excellent
Catalog No. T25915Alias PAI-749, PAI749Cas No. 481631-45-2
Diaplasinin (PAI-749) is a highly efficient inhibitor of plasminogen activator inhibitor-1 (PAI-1) with antithrombotic activity. It can be used in cardiovascular disease research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $789 | In Stock | |
| 100 mg | $1,280 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Diaplasinin"
Tiplaxtinin
Cited
Tiplasinin, PAI-039
T2030393105-53-8
Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.
- $37
Size
QTY
CitedAngstrom6
A-6 peptide, A6 peptide, A-6, A6, A 6 peptide, A 6
T26629220334-14-5
Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade and abrogates the downstream effects.Angstrom6 has antitumor activity and inhibits tumor cell migration, invasion, and metastasis by binding to CD44 and modulating CD44-mediated cell signaling.
- $49
Size
QTY
UK-371804
UK371804
T3442256477-09-5
UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers.
- $44
Size
QTY
Toddalolactone
(+)-Toddalolactone
T4S0592483-90-9
Toddalolactone ((+)-Toddalolactone) is an anti-inflammatory and analgesic.
- $100
Size
QTY
TM5275 sodium
Cited
TM5275 sodium salt
T42551103926-82-4
TM5275 sodium (TM5275 sodium salt) is an inhibitor of plasminogen activator inhibitor 1 (PAI-1).
- $35
Size
QTY
CitedTM5441 Cited
T42541190221-43-2
TM5441 is an orally bioavailable fibrinogen activator inhibitor-1 inhibitor that inhibits several cancer cell lines with IC50 values ranging from 13.9 to 51.1 μM.It induces intrinsic cell death in several human cancer cells and attenuates Nω-nitro-1-arginine methyl ester-induced cardiac hypertension and vascular senescence.
- $34
Size
QTY
CitedAleplasinin
PAZ-417, PAZ417, PAZ 417
T29856481629-87-2
Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic system. Aleplasinin can be used in Alzheimer's disease studies.
- $52
Size
QTY
AZ3976
AZ-3976, AZ 3976
T237641418747-15-5
AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.
- $30
Size
QTY
GW-6604
T9947452342-37-9In house
GW-6604, an ALK5 inhibitor, exhibits clear antifibrotic effects leading to improved liver function.
- $30
Size
QTY
Upamostat
T13257590368-25-5
Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.
- $97
Size
QTY
Loureirin B
T3876119425-90-0
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved.
- $48
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | Diaplasinin (PAI-749) is a highly efficient inhibitor of plasminogen activator inhibitor-1 (PAI-1) with antithrombotic activity. It can be used in cardiovascular disease research. |
| Targets&IC50 | PAI1:295 nM, TPA:157 nM, uPA:87 nM, labeled PAI1:140 nM, labeled PAI1:254 nM (Kd) |
| In vitro | Diaplasinin is an inhibitor targeting plasminogen activator inhibitor 1 (PAI-1) with an IC50 of 295 nM.[1] Diaplasinin inhibits PAI-1 synthesis with high potency and selectivity, and maintains tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) activity in the presence of PAI-1, with IC50s of 157 nM and 87 nM, respectively. In addition, Diaplasinin exhibits an apparent Kd value of 254 nM and an IC50 value of 140 nM by quenching the fluorescence of fluorescently labeled PAI-1. [2] |
| Alias | PAI-749, PAI749 |
| Molecular Weight | 501.62 |
| Formula | C32H31N5O |
| Cas No. | 481631-45-2 |
| Smiles | N1=NNC(=N1)COC=2C=CC3=CC(=CC=C3C2)C4=C(C5=CC=CC=C5N4CC=6C=CC=CC6)CCCCC |
| Relative Density. | 1.21g/cm3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (199.35 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Diaplasinin | purchase Diaplasinin | Diaplasinin cost | order Diaplasinin | Diaplasinin chemical structure | Diaplasinin in vitro | Diaplasinin formula | Diaplasinin molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.