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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $44 | In Stock | |
2 mg | $61 | In Stock | |
5 mg | $110 | In Stock | |
10 mg | $189 | In Stock | |
25 mg | $341 | In Stock | |
50 mg | $512 | In Stock | |
100 mg | $743 | In Stock | |
500 mg | $1,550 | In Stock | |
1 mL x 10 mM (in DMSO) | $119 | In Stock |
Description | UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers. |
Targets&IC50 | uPA:10 nM. (Ki) |
In vitro | In the acute excision wound model in pigs, topical administration of UK-3718046 penetrates porcine wounds and inhibits exogenous uPA activity without adverse effects on wound-healing parameters. |
In vivo | In vitro studies have shown that UK-3718046 is an inhibitor of exogenous uPA in human chronic wound fluid, displaying inhibitory capabilities with an IC50 of 0.89 μM. |
Alias | UK371804 |
Molecular Weight | 385.83 |
Formula | C14H16ClN5O4S |
Cas No. | 256477-09-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 8 mg/mL (20.73 mM), Sonication and heating are recommended. ![]() | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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