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AZ3976

🥰Excellent
Catalog No. T23764Cas No. 1418747-15-5
Alias AZ-3976, AZ 3976

AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.

AZ3976

AZ3976

🥰Excellent
Purity: 98.01%
Catalog No. T23764Alias AZ-3976, AZ 3976Cas No. 1418747-15-5
AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.
Pack SizePriceAvailabilityQuantity
2 mg28 €In Stock
5 mg45 €In Stock
10 mg73 €In Stock
25 mg138 €In Stock
50 mg207 €In Stock
100 mg306 €In Stock
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Purity:98.01%
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Product Introduction

Bioactivity
Description
AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.
In vitro
AZ3976 is active with an IC50 value of 26 μM in an enzymatic chromogenic assay. AZ3976 enhances the latency transition of active PAI-1 and inhibits PAI-1[1].
AliasAZ-3976, AZ 3976
Chemical Properties
Molecular Weight317.34
FormulaC15H19N5O3
Cas No.1418747-15-5
SmilesO=C1C=2C(NC(NC3CN(C(OC(C)(C)C)=O)C3)=N1)=NC=CC2
Relative Density.1.42 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (141.8 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1512 mL15.7560 mL31.5119 mL157.5597 mL
5 mM0.6302 mL3.1512 mL6.3024 mL31.5119 mL
10 mM0.3151 mL1.5756 mL3.1512 mL15.7560 mL
20 mM0.1576 mL0.7878 mL1.5756 mL7.8780 mL
50 mM0.0630 mL0.3151 mL0.6302 mL3.1512 mL
100 mM0.0315 mL0.1576 mL0.3151 mL1.5756 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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