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AZ3976

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Purity:98.01%

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COA HNMR HPLC

AZ3976

Catalog No. T23764Cas No. 1418747-15-5

AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.

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Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$97	In Stock
10 mg	$166	In Stock
25 mg	$352	In Stock
50 mg	$492	In Stock
100 mg	$696	In Stock
1 mL x 10 mM (in DMSO)	$127	In Stock

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Product Introduction

Bioactivity

Description	AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.
In vitro	AZ3976 is active with an IC50 value of 26 μM in an enzymatic chromogenic assay. AZ3976 enhances the latency transition of active PAI-1 and inhibits PAI-1[1].
Alias	AZ 3976, AZ-3976

Chemical Properties

Molecular Weight	317.34
Formula	C15H19N5O3
Cas No.	1418747-15-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (141.8 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1512 mL	15.7560 mL	31.5119 mL	157.5597 mL
5 mM	0.6302 mL	3.1512 mL	6.3024 mL	31.5119 mL
10 mM	0.3151 mL	1.5756 mL	3.1512 mL	15.7560 mL
20 mM	0.1576 mL	0.7878 mL	1.5756 mL	7.8780 mL
50 mM	0.0630 mL	0.3151 mL	0.6302 mL	3.1512 mL
100 mM	0.0315 mL	0.1576 mL	0.3151 mL	1.5756 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc