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DL-AP5 lithium
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Catalog No. T201724Cas No. 125229-62-1
Alias DL-2-Amino-5-phosphonovaleric acid lithium, 2-APV lithium
DL-AP5 (2-APV) lithium is a competitive antagonist of the NMDA (N-Methyl-D-aspartate) receptor. It exhibits notable analgesic activity and specifically blocks channels in the rabbit retina.
DL-AP5 lithium
😃Good
Catalog No. T201724Alias DL-2-Amino-5-phosphonovaleric acid lithium, 2-APV lithiumCas No. 125229-62-1
DL-AP5 (2-APV) lithium is a competitive antagonist of the NMDA (N-Methyl-D-aspartate) receptor. It exhibits notable analgesic activity and specifically blocks channels in the rabbit retina.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | DL-AP5 (2-APV) lithium is a competitive antagonist of the NMDA (N-Methyl-D-aspartate) receptor. It exhibits notable analgesic activity and specifically blocks channels in the rabbit retina. |
| In vitro | DL-AP5 (100 μM) mitigates the elevation of Arc/Arg3.1 protein levels caused by glutamate exposure and reduces NMDA-induced upregulation of Arc/Arg3.1. |
| In vivo | DL-AP5, when administered intra-CA1 (0-10 μg/rat), significantly diminishes NMDA's effects. At a range of 0-10 nmol via intracerebroventricular injection, it elicits a dose-dependent escalation in food intake. Moreover, a specific dose of 5 nmol of DL-AP5 via the same route effectively mitigates the reduction in food consumption that is typically prompted by an intracerebroventricular injection of ghrelin. |
| Alias | DL-2-Amino-5-phosphonovaleric acid lithium, 2-APV lithium |
| Molecular Weight | 203.06 |
| Formula | C5H11LiNO5P |
| Cas No. | 125229-62-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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