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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | DSO-5a, a potent and selective orally active BB3 agonist, is a DMAKO-00 derivative that enhances ppar-γ activity via BB3 and stimulates ERK1/2 phosphorylation. It is utilized in diabetes-related research [1]. |
In vitro | DSO-5a (50 nM; 60min) induced IP-1 accumulation in hBB3-HEK cells with a pEC50 of 8.485 and elicited a potent calcium response with a pEC50 value of 7.964 [1]. At a higher concentration, DSO-5a (500 nM; 60min) prompted IP-1 accumulation in mBB3-HEK cells with a pEC50 of 7.262 and stimulated a strong calcium response with a pEC50 value of 7.174 [1]. Additionally, DSO-5a demonstrated dose-dependent activation of ERK1/2 in both hBB3-H1299 and mBB3-HEK cells over a concentration range of 0-100 nM within 8 minutes [1]. |
In vivo | DSO-5a (3-30 mg/kg; P.O.; 30 minutes) dose-dependently reduced glycemic variability in C57BL/6 mice [1]. Additionally, DSO-5a (10 mg/kg/day; P.O.; 2-4 weeks) lowered blood glucose levels in diabetic db/db mice [1]. |
Molecular Weight | 440.45 |
Formula | C23H24N2O7 |
Cas No. | 2195411-63-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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