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DSO-5a
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Catalog No. T79231Cas No. 2195411-63-1
DSO-5a, a potent and selective orally active BB3 agonist, is a DMAKO-00 derivative that enhances ppar-γ activity via BB3 and stimulates ERK1/2 phosphorylation. It is utilized in diabetes-related research [1].
DSO-5a
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Catalog No. T79231Cas No. 2195411-63-1
DSO-5a, a potent and selective orally active BB3 agonist, is a DMAKO-00 derivative that enhances ppar-γ activity via BB3 and stimulates ERK1/2 phosphorylation. It is utilized in diabetes-related research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | DSO-5a, a potent and selective orally active BB3 agonist, is a DMAKO-00 derivative that enhances ppar-γ activity via BB3 and stimulates ERK1/2 phosphorylation. It is utilized in diabetes-related research [1]. |
| In vitro | DSO-5a (50 nM; 60min) induced IP-1 accumulation in hBB3-HEK cells with a pEC50 of 8.485 and elicited a potent calcium response with a pEC50 of 7.964 [1]. At 500 nM, it induced IP-1 accumulation in mBB3-HEK cells with a pEC50 of 7.262 and a calcium response with a pEC50 of 7.174 [1]. DSO-5a also activated ERK1/2 in both hBB3-H1299 and mBB3-HEK cells in a dose-dependent manner (0-100 nM) within 8 minutes [1]. |
| In vivo | DSO-5a (3-30 mg/kg; P.O.; 30 minutes) dose-dependently reduced glycemic variability in C57BL/6 mice [1], and at 10 mg/kg/day for 2-4 weeks, it lowered blood glucose levels in diabetic db/db mice [1]. |
| Molecular Weight | 440.45 |
| Formula | C23H24N2O7 |
| Cas No. | 2195411-63-1 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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