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EGFR-IN-73
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EGFR-IN-73
Catalog No. T73165Cas No. 2857033-34-0
EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1]. |
| In vitro | EGFR-IN-73 (Compound 3f), ranging from 0.01 nM to 10 μM over 72 hours, exhibits low activity against wild-type EGFR and potently binds to EGFR mutants including EGFR d746-750 (Del19), EGFR d747-752/P753S, and EGFR L858R, as well as to a lesser extent with EGFR d752-759 and the oncogenic mutants FLT3 D835Y and FLT3 ITD D835V. The compound demonstrates excellent chemical stability, retaining over 95% under acidic conditions after 3 hours and maintaining above 80% stability at neutral pH 7.4. |
| Molecular Weight | 405.81 |
| Formula | C19H17ClFN3O4 |
| Cas No. | 2857033-34-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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