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EGFR-IN-73
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Catalog No. T73165Cas No. 2857033-34-0
EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, with an IC50 value of 119 nM [1].
EGFR-IN-73
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Catalog No. T73165Cas No. 2857033-34-0
EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, with an IC50 value of 119 nM [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, with an IC50 value of 119 nM [1]. |
| Targets&IC50 | EGFR (L858R):820 nM, EGFR (L858R/T790M):>10 μM, EGFR del19:119 nM, EGFR WT:>10 μM |
| In vitro | EGFR-IN-73 (Compound 3f), ranging from 0.01 nM to 10 μM over 72 hours, exhibits low activity against wild-type EGFR and potently binds to EGFR mutants including EGFR d746-750 (Del19), EGFR d747-752/P753S, and EGFR L858R, as well as to a lesser extent with EGFR d752-759 and the oncogenic mutants FLT3 D835Y and FLT3 ITD D835V. The compound demonstrates excellent chemical stability, retaining over 95% under acidic conditions after 3 hours and maintaining above 80% stability at neutral pH 7.4. |
| Molecular Weight | 405.81 |
| Formula | C19H17ClFN3O4 |
| Cas No. | 2857033-34-0 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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