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EMD57439

EMD57439
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Purity:99.38%
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EMD57439

Catalog No. T25373Cas No. 148714-88-9
EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).
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Pack SizePriceAvailabilityQuantity
1 mg$195In Stock
5 mg$465In Stock
10 mg$679In Stock
25 mg$1,070In Stock
50 mg$1,430In Stock
100 mg$1,930In Stock
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Product Introduction

Bioactivity
Description
EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).
In vitro
EMD 57033 (10 microM) slightly increased the rate of relaxation (rate constant k1 changing from 24.0 +/- 2.9 s-1 in control to 28.1 +/- 3.2 s-1) but had no significant effect on the rate of activation (k1 = 9.6 +/- 0.9 s-1 in control conditions, 9.7 +/- 1.6 s-1 with EMD 57033).[2]
AliasEMD-57439, EMD 57439
Chemical Properties
Molecular Weight425.5
FormulaC22H23N3O4S
Cas No.148714-88-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 22.5 mg/mL (52.88 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3502 mL11.7509 mL23.5018 mL117.5088 mL
5 mM0.4700 mL2.3502 mL4.7004 mL23.5018 mL
10 mM0.2350 mL1.1751 mL2.3502 mL11.7509 mL
20 mM0.1175 mL0.5875 mL1.1751 mL5.8754 mL
50 mM0.0470 mL0.2350 mL0.4700 mL2.3502 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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