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Endothelin-1 (1-31) (Human) TFA
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Catalog No. T78063
Endothelin-1 (1-31) (Human) TFA, a potent vasoconstrictor and hypertensive agent, originates from chymase-mediated selective hydrolysis of big ET-1 [1].
Endothelin-1 (1-31) (Human) TFA
Endothelin-1 (1-31) (Human) TFA
😃Good
Catalog No. T78063
Endothelin-1 (1-31) (Human) TFA, a potent vasoconstrictor and hypertensive agent, originates from chymase-mediated selective hydrolysis of big ET-1 [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Endothelin-1 (1-31) (Human) TFA, a potent vasoconstrictor and hypertensive agent, originates from chymase-mediated selective hydrolysis of big ET-1 [1]. |
| In vitro | Endothelin-1 (1-31) (Human) induces proliferation of human mesangial cells at concentrations of 100 pM to 100 nM over 24 hours and triggers ERK activation at 100 nM within 0 to 10 minutes [2]. |
| In vivo | ET-1 (1-31) (100 nM; single dose) TFA induces constriction of mesenteric arteries in mice, likely mediated by ET A receptors, with potential age-related increases, and notable gender differences observed in chronic diabetes [1]. |
| Molecular Weight | 3742.18 |
| Formula | C164H237F3N38O49S5 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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