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Epiroprim
🥰Excellent
Catalog No. T25381Cas No. 73090-70-7
Alias Ro11-8958, Ro-11-8958, Ro 11-8958, RO 118958, Epiroprime
Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor with antibacterial activity, inhibiting Staphylococcus, Enterococcus, Pneumococcus, and Streptococcus.
Epiroprim
🥰Excellent
Purity: 100%
Catalog No. T25381Alias Ro11-8958, Ro-11-8958, Ro 11-8958, RO 118958, EpiroprimeCas No. 73090-70-7
Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor with antibacterial activity, inhibiting Staphylococcus, Enterococcus, Pneumococcus, and Streptococcus.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $718 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor with antibacterial activity, inhibiting Staphylococcus, Enterococcus, Pneumococcus, and Streptococcus. |
| Targets&IC50 | DHFR:0.9 μmol |
| In vitro | The 50% inhibitory concentration (IC50) of Epiroprim against Toxoplasma gondii dihydrofolate reductase was 0.9 μmol. [1] Epiroprim has bactericidal effect with a minimum inhibitory activity of 10 mg/L against Mycobacterium leprae. [3] |
| In vivo | Epiroprim (300 mg/kg/ day for 14 days, given intraperitoneally) was ineffective against mice acutely infected with the RH strain of Toxoplasma Gondii, but when Epiroprim was combined with oral sulfadiazine (375 mg/kg/ day), a 100% survival rate was seen. [1] Epiroprim (100 mg/kg) combined with dapsone can prevent pneumosporosis and toxoplasmosis in rats. [2] |
| Alias | Ro11-8958, Ro-11-8958, Ro 11-8958, RO 118958, Epiroprime |
| Molecular Weight | 353.42 |
| Formula | C19H23N5O2 |
| Cas No. | 73090-70-7 |
| Smiles | N=1C=C(C(=NC1N)N)CC2=CC(OCC)=C(C(OCC)=C2)N3C=CC=C3 |
| Relative Density. | 1.2174 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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