Etimizol (Ethimizole) was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of the brain). The positive effect of Etimizol on memory is related to its influence on the consolidation stage.

When applied extracellularly at concentrations of 5-10 mM/L, Etimizol (Ethymisole) specifically alters the behavior of giant neurons in the isolated nervous system of Coretus corneus, notably increasing the duration of action potentials, slowing the development of the descending phase, and reducing the amplitude of trace hyperpolarization. The interval between the administration of Etimizol (3 mg/kg) and the initiation of learning in various experiments ranged from 0.5 to 3 hours. However, regardless of the timing and biological reinforcement method, Etimizol (Ethymisole) did not enhance learning capabilities in rats. Furthermore, following doses of 10 or 1 mg/loop of Etimizol, the average residence time of the compound in the loop was recorded at 20.1 and 7.6 minutes, with standard deviations of 3.1 and 0.8 minutes, respectively.