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Etiprednol dicloacetate

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Purity:99.43%

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COA HNMR HPLC LCMS

Etiprednol dicloacetate

Catalog No. T31719Cas No. 199331-40-3

Etiprednol dicloacetate (BNP-166) is a corticosteroid with anti-inflammatory activity.Etiprednol dicloacetate inhibits the accumulation of eosinophils and can be used in the study of inflammatory airway diseases such as asthma and in the treatment of Crohn's disease.

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Pack Size	Price	Availability
1 mg	$112	In Stock
5 mg	$260	In Stock
10 mg	$390	In Stock
25 mg	$653	In Stock
50 mg	$928	In Stock
100 mg	$1,260	In Stock

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Product Introduction

Bioactivity

Description	Etiprednol dicloacetate (BNP-166) is a corticosteroid with anti-inflammatory activity.Etiprednol dicloacetate inhibits the accumulation of eosinophils and can be used in the study of inflammatory airway diseases such as asthma and in the treatment of Crohn's disease.
In vitro	Etiprednol dicloacetate (1 nM-1 μM) inhibits LPS-induced TNF-α production in human blood.[1]
In vivo	Etiprednol dicloacetate (0-100 μg/kg; intranasal inhalation) reduces peribronchial eosinophilia in the lungs of allergen-sensitized and challenged rats.[1] It is well-tolerated in rats and dogs at doses of up to 20 mg/kg administered orally over 28 days.[2] Etiprednol dicloacetate (0.1 μg/kg; intranasal inhalation) inhibits eosinophil accumulation in rats induced by antigen exposure.[3]
Alias	BNP 166, BNP166, BNP-166

Chemical Properties

Molecular Weight	485.4
Formula	C24H30Cl2O6
Cas No.	199331-40-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (113.31 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0602 mL	10.3008 mL	20.6016 mL	103.0078 mL
5 mM	0.4120 mL	2.0602 mL	4.1203 mL	20.6016 mL
10 mM	0.2060 mL	1.0301 mL	2.0602 mL	10.3008 mL
20 mM	0.1030 mL	0.5150 mL	1.0301 mL	5.1504 mL
50 mM	0.0412 mL	0.2060 mL	0.4120 mL	2.0602 mL
100 mM	0.0206 mL	0.1030 mL	0.2060 mL	1.0301 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Keywords

Etiprednol dicloacetate