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FKBP12 PROTAC RC32
🥰Excellent
Catalog No. T13694Cas No. 2375555-66-9
Alias RC32
FKBP12 PROTAC RC32 is a PROTAC-like degrader targeting FKBP12. It can degrade FKBP12 in organs after intraperitoneal administration.
FKBP12 PROTAC RC32
🥰Excellent
Purity: 99.57%
Catalog No. T13694Alias RC32Cas No. 2375555-66-9
FKBP12 PROTAC RC32 is a PROTAC-like degrader targeting FKBP12. It can degrade FKBP12 in organs after intraperitoneal administration.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $215 | In Stock |
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Purity:99.57%
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Product Introduction
Bioactivity
Chemical Properties
| Description | FKBP12 PROTAC RC32 is a PROTAC-like degrader targeting FKBP12. It can degrade FKBP12 in organs after intraperitoneal administration. |
| In vitro | RC32 induced FKBP12 degradation in Hep3B and HuH7 with DC50 values at 0.9 and 0.4 nM. [2] RC32 demonstrated the ability for FKBP12 degradation resulted in 50% protein degradation (DC50) of ~0.3 nM after only 12 h of treatment in Jurkat cells. [3] |
| In vivo | The FKBP12 protein in most of the organs of treated mice, except for the brain, was undetectable after only 1 day of treatment with RC32 (intraperitoneal (i.p.) injection, 30 mg/kg, twice a day). A significant degradation of FKBP12 also occurred in the eyes. RC32 had no effect on FKBP12 degradation in brain tissues. [3] When Bama pigs (20 kg) were given RC32 (8 mg/kg, twice a day) for 2 days, the FKBP12 protein was efficiently degraded in most of the organs examined. [3] After 3 days of administration (8 mg/kg, i.p., twice a day), FKBP12 in the heart, liver, kidney, spleen, lung, and stomach of monkeys was efficiently degraded by RC32. [3] |
| Alias | RC32 |
| Molecular Weight | 1426.69 |
| Formula | C75H107N7O20 |
| Cas No. | 2375555-66-9 |
| Smiles | O=C1NC(C(N2C(C(C=CC=C3NCCOCCOCCN4C=C(COCCO[C@H]5CC[C@@H](C[C@H]([C@](OC([C@@]6([H])N(C(C([C@]7(O)O[C@@]8([H])CC[C@H]7C)=O)=O)CCCC6)=O)([H])CC([C@@H](/C=C(C)\[C@@H](O)[C@@H](OC)C([C@H](C)C[C@H](C)/C=C\C=C\C=C(C)/[C@@H](OC)C8)=O)C)=O)C)C[C@H]5OC)N=N4)=C3C2=O)=O)CC1)=O |
| Relative Density. | 1.31 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 5 mg/mL (3.50 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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