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gp91 ds-tat

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Catalog No. T80243Cas No. 329902-61-6

gp91 ds-tat is a NADPH oxidase (NOX2) inhibitor that reduces NOX2 expression.

gp91 ds-tat

gp91 ds-tat

😃Good
Purity: 98.27%
Catalog No. T80243Cas No. 329902-61-6
gp91 ds-tat is a NADPH oxidase (NOX2) inhibitor that reduces NOX2 expression.
Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
5 mg$1487-10 days
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Purity:98.27%
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Product Introduction

Bioactivity
Description
gp91 ds-tat is a NADPH oxidase (NOX2) inhibitor that reduces NOX2 expression.
In vitro
Using confocal microscopy, Hcy induced formation of NLRP3 inflammasomes as indicated by increased colocalization of inflammasome markers, NLRP3 with ASC, and NLRP3 with caspase-1. Pretreatment with the ROS scavenger, catalase (50 U/ml), or gp91 ds-tat peptide blocked this increase. [1]
Chemical Properties
Molecular Weight2452.94
FormulaC98H190N50O22S
Cas No.329902-61-6
Smiles[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CS)=O)CO)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)CCCNC(=N)N
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL（32.61 mM), Sonication is recommended.
H2O: < 0.1 mg/mL (insoluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.4077 mL2.0384 mL4.0767 mL20.3837 mL
5 mM0.0815 mL0.4077 mL0.8153 mL4.0767 mL
10 mM0.0408 mL0.2038 mL0.4077 mL2.0384 mL
20 mM0.0204 mL0.1019 mL0.2038 mL1.0192 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NADPHoxidase
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