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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $84 | In Stock | |
5 mg | $197 | In Stock | |
10 mg | $372 | In Stock | |
25 mg | $629 | In Stock | |
50 mg | $896 | In Stock | |
100 mg | $1,220 | In Stock | |
500 mg | $2,450 | In Stock | |
1 mL x 10 mM (in DMSO) | $226 | In Stock |
Description | VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX activity. |
In vitro | VAS 3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.[1] VAS 3947 (30 µM) does not interfere with xanthine/XOD-derived L012 signals, suggesting this compound is free of antioxidant or scavenging effects relevant to ROS detection.[4] VAS 3947 attenuates platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC3.[5] |
Alias | VA-S3947, VA S3947, VAS3947 |
Molecular Weight | 310.33 |
Formula | C14H10N6OS |
Cas No. | 869853-70-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90.0 mg/mL (290.0 mM ) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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