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VAS 3947

VAS 3947
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Purity:98.44%
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VAS 3947

Catalog No. T29097Cas No. 869853-70-3
VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX activity.
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Pack SizePriceAvailabilityQuantity
1 mg$84In Stock
5 mg$197In Stock
10 mg$372In Stock
25 mg$629In Stock
50 mg$896In Stock
100 mg$1,220In Stock
500 mg$2,450In Stock
1 mL x 10 mM (in DMSO)$226In Stock
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Product Introduction

Bioactivity
Description
VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX activity.
In vitro
VAS 3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.[1]
VAS 3947 (30 µM) does not interfere with xanthine/XOD-derived L012 signals, suggesting this compound is free of antioxidant or scavenging effects relevant to ROS detection.[4]
VAS 3947 attenuates platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC3.[5]
AliasVA-S3947, VA S3947, VAS3947
Chemical Properties
Molecular Weight310.33
FormulaC14H10N6OS
Cas No.869853-70-3
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 90.0 mg/mL (290.0 mM )
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2224 mL16.1119 mL32.2238 mL161.1188 mL
5 mM0.6445 mL3.2224 mL6.4448 mL32.2238 mL
10 mM0.3222 mL1.6112 mL3.2224 mL16.1119 mL
20 mM0.1611 mL0.8056 mL1.6112 mL8.0559 mL
50 mM0.0644 mL0.3222 mL0.6445 mL3.2224 mL
100 mM0.0322 mL0.1611 mL0.3222 mL1.6112 mL

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