Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

VAS 3947

Catalog No. T29097Cas No. 869853-70-3
Alias VA-S3947, VAS3947, VA S3947

VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX activity.

VAS 3947

VAS 3947

Purity: 98.44%
Catalog No. T29097Alias VA-S3947, VAS3947, VA S3947Cas No. 869853-70-3
VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX activity.
Pack SizePriceAvailabilityQuantity
1 mg$68In Stock
5 mg$163In Stock
10 mg$297In Stock
25 mg$519In Stock
50 mg$745In Stock
100 mg$987In Stock
1 mL x 10 mM (in DMSO)$179In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "VAS 3947"

Select Batch
Purity:98.44%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX activity.
Targets&IC50
MV-4-11 cells:2.6±0.6µM, THP1:4.9µM, ROS:12 µM
In vitro
VAS 3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.[1]
VAS 3947 (30 µM) does not interfere with xanthine/XOD-derived L012 signals, suggesting this compound is free of antioxidant or scavenging effects relevant to ROS detection.[4]
VAS 3947 attenuates platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC3.[5]
AliasVA-S3947, VAS3947, VA S3947
Chemical Properties
Molecular Weight310.33
FormulaC14H10N6OS
Cas No.869853-70-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90.0 mg/mL (290.0 mM ), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2224 mL16.1119 mL32.2238 mL161.1188 mL
5 mM0.6445 mL3.2224 mL6.4448 mL32.2238 mL
10 mM0.3222 mL1.6112 mL3.2224 mL16.1119 mL
20 mM0.1611 mL0.8056 mL1.6112 mL8.0559 mL
50 mM0.0644 mL0.3222 mL0.6445 mL3.2224 mL
100 mM0.0322 mL0.1611 mL0.3222 mL1.6112 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy VAS 3947 | purchase VAS 3947 | VAS 3947 cost | order VAS 3947 | VAS 3947 chemical structure | VAS 3947 in vitro | VAS 3947 formula | VAS 3947 molecular weight