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APX-115 free base

🥰Excellent
Catalog No. T10353Cas No. 1270084-92-8
Alias Ewha-18278 free base

APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with inhibition constants (Kis) of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4, respectively, and it effectively prevents kidney injury.

APX-115 free base

APX-115 free base

🥰Excellent
Purity: 99.03%
Catalog No. T10353Alias Ewha-18278 free baseCas No. 1270084-92-8
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with inhibition constants (Kis) of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4, respectively, and it effectively prevents kidney injury.
Pack SizePriceAvailabilityQuantity
1 mg$51In Stock
5 mg$122In Stock
10 mg$198In Stock
25 mg$397In Stock
50 mg$595In Stock
100 mg$866In Stock
1 mL x 10 mM (in DMSO)$125In Stock
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Purity:99.03%
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Product Introduction

Bioactivity
Description
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with inhibition constants (Kis) of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4, respectively, and it effectively prevents kidney injury.
Targets&IC50
NOX2:0.57 μM (ki), Nox4:0.63 μM (ki), NOX1:ki:1.08 μM
In vitro
In the mouse podocyte cell line, APX-115 free base (5?μM; 60?min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression. In the kidney, APX-115 free base attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes [2].
In vivo
APX-115 free base treatment decreases the urinary excretion of albumin and plasma creatinine levels. APX-115 (oral gavage; 60?mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice.
AliasEwha-18278 free base
Chemical Properties
Molecular Weight279.34
FormulaC17H17N3O
Cas No.1270084-92-8
SmilesCCCc1c(O)n(nc1-c1ccccc1)-c1ccccn1
Relative Density.1.17 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 245 mg/mL (877.07 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5799 mL17.8993 mL35.7987 mL178.9933 mL
5 mM0.7160 mL3.5799 mL7.1597 mL35.7987 mL
10 mM0.3580 mL1.7899 mL3.5799 mL17.8993 mL
20 mM0.1790 mL0.8950 mL1.7899 mL8.9497 mL
50 mM0.0716 mL0.3580 mL0.7160 mL3.5799 mL
100 mM0.0358 mL0.1790 mL0.3580 mL1.7899 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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