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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $149 | In Stock |
Description | GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase. It has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as adjunctive therapy for treating inflammation. |
Targets&IC50 | RIP3:6.5 nM, RIP3:8.6 nM |
In vitro | RIP3i GSK-843 and GSK-872 by screening conventional small molecule libraries. These compounds bound RIP3 kinase domain with high affinity (IC50 = 8.6 nM and 1.8 nM, respectively,and inhibited kinase activity (IC50 = 6.5 nM and 1.3 nM, respectively[1]. |
Alias | GSK'843 |
Molecular Weight | 377.49 |
Formula | C19H15N5S2 |
Cas No. | 1601496-05-2 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (79.47 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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