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GSK-843

🥰Excellent
Catalog No. T11474Cas No. 1601496-05-2
Alias GSK'843

GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase. It has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as adjunctive therapy for treating inflammation.

GSK-843

GSK-843

🥰Excellent
Purity: 99.18%
Catalog No. T11474Alias GSK'843Cas No. 1601496-05-2
GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase. It has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as adjunctive therapy for treating inflammation.
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1 mg$149In Stock
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Purity:99.18%
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Product Introduction

Bioactivity
Description
GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase. It has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as adjunctive therapy for treating inflammation.
Targets&IC50
RIP3:6.5 nM, RIP3:8.6 nM
In vitro
RIP3i GSK-843 and GSK-872 by screening conventional small molecule libraries. These compounds bound RIP3 kinase domain with high affinity (IC50 = 8.6 nM and 1.8 nM, respectively,and inhibited kinase activity (IC50 = 6.5 nM and 1.3 nM, respectively[1].
AliasGSK'843
Chemical Properties
Molecular Weight377.49
FormulaC19H15N5S2
Cas No.1601496-05-2
SmilesCc1cc(-c2cnc(N)c3c(csc23)-c2ccc3scnc3c2)n(C)n1
Relative Density.1.54 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (79.47 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6491 mL13.2454 mL26.4908 mL132.4538 mL
5 mM0.5298 mL2.6491 mL5.2982 mL26.4908 mL
10 mM0.2649 mL1.3245 mL2.6491 mL13.2454 mL
20 mM0.1325 mL0.6623 mL1.3245 mL6.6227 mL
50 mM0.0530 mL0.2649 mL0.5298 mL2.6491 mL

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