rip3

GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.

Citronellol ((±)-β-Citronellol) is used in insect repellents and perfumes and as a mite attractant.

GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase. It has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as adjunctive therapy for treating inflammation.

GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor that binds to the RIP3 kinase domain (IC50: 0.9 nM) and inhibits kinase activity (IC50: 0.3 nM).

GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).

(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.

HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.

GSK872 HCl（1346546-69-7 free base） (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).

RIPK3-IN-2, a RIP3 inhibitor, is utilized in studies of diseases caused by or associated with activated necrotic pathways.

(R)-Citronellol ((R)-(+)-β-Citronellol) is found in herbs and spices, as well as bilberry. (R)-Citronellol is a constituent of black cumin (Nigella sativa) seeds. (R)-Citronellol is a common constituent of plant oils, especially in the Rutaceae.

Clethodim is a acetyl-coenzyme A carboxylase (ACCase)-inhibiting cyclohexanedione herbicide.

L-Citronellol ((S)-(-)-beta-Citronellol) is a small molecule compound isolated from geranium with antifungal activity, affecting fungal membranes.L-Citronellol acts synergistically with amphotericin B against Candida yeast.