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GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $116 | In Stock | |
5 mg | $289 | In Stock | |
10 mg | $455 | In Stock | |
25 mg | $763 | In Stock | |
50 mg | $1,070 | In Stock | |
100 mg | $1,430 | In Stock | |
1 mL x 10 mM (in DMSO) | $318 | In Stock |
Description | GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3. |
In vitro | GSK2593074A (GSK'074) (0.01, 0.1, 1, 10, and 100 nM; 6 h) fully prevents necroptosis across various stimuli in both human and murine cells with IC50~3 nM, including MOVAS cells and L929 cells.[1] |
In vivo | GSK2593074A (GSK'074) (0.93 mg/kg/day; i.p.; 14 or 28 days; mice) show significantly alleviated aneurysm formation, reflected by a much smaller aortic dilatation (36.28±5.76%; P<0.05) as well as a reduced abdominal aortic aneurysm (AAA) incidence (from 83.3 to 16.7%). GSK2593074A significantly decreases the extent of aortic expansion (27.36±8.25%; P<0.05). Inhibited aneurysm formation in mouse models of aneurysms.[1] |
Alias | GSK'074 |
Molecular Weight | 465.57 |
Formula | C27H23N5OS |
Cas No. | 1337531-06-2 |
Smiles | Cn1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc2N(CCc2c1)C(=O)Cc1ccccc1 |
Relative Density. | 1.39 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 41.67 mg/mL (89.50 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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