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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $48 | In Stock | |
5 mg | $97 | In Stock | |
10 mg | $169 | In Stock | |
25 mg | $353 | In Stock | |
50 mg | $538 | In Stock | |
100 mg | $777 | In Stock | |
1 mL x 10 mM (in DMSO) | $118 | In Stock |
Description | HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM. |
In vitro | HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action.?Moreover, the compound inhibited TNF-induced necroptosis but did not inhibit TNF-induced apoptosis, indicating that this novel inhibitor has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity.?HS-1371 could serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation. |
Molecular Weight | 384.47 |
Formula | C24H24N4O |
Cas No. | 2158197-70-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 16.67 mg/mL (43.36 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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