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HS-1371
🥰Excellent
Catalog No. T6815Cas No. 2158197-70-5
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
HS-1371
🥰Excellent
Purity: 98%
Catalog No. T6815Cas No. 2158197-70-5
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $97 | In Stock | |
| 10 mg | $169 | In Stock | |
| 25 mg | $353 | In Stock | |
| 50 mg | $538 | In Stock | |
| 100 mg | $777 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $118 | In Stock |
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Purity:98%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM. |
| Targets&IC50 | RIP3:20.8 nM |
| In vitro | HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, inhibiting TNF-induced necroptosis without affecting TNF-induced apoptosis. This indicates a specific inhibitory effect on RIP3-mediated necroptosis through the suppression of RIP3 kinase activity. HS-1371 may serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation. |
| Molecular Weight | 384.47 |
| Formula | C24H24N4O |
| Cas No. | 2158197-70-5 |
| Smiles | Cc1ccc(Oc2ccnc3cc(ccc23)-c2cnn(c2)C2CCNCC2)cc1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 16.67 mg/mL (43.36 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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