Shopping Cart
- Remove All
- Your shopping cart is currently empty
Ganfeborole HCl (GSK3036656 HCl) is a small molecule compound with anti-tuberculosis activity and is an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS; IC50: 0.2 μM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $299 | In Stock |
Description | Ganfeborole HCl (GSK3036656 HCl) is a small molecule compound with anti-tuberculosis activity and is an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS; IC50: 0.2 μM). |
Targets&IC50 | LeuRS (Mtb):0.2 μM |
In vitro | GSK3036656 shows potent inhibition of Mtb LeuRS (IC50 = 0.20 μM) and in vitro antitubercular activity (Mtb H37Rv MIC = 0.08 μM). Additionally, it is highly selective for the Mtb LeuRS enzyme with IC50 of >300 μM and 132 μM for human mitochondrial LeuRS and human cytoplasmic LeuRS, respectively[1]. |
In vivo | GSK3036656 (0.4 mg/kg) demonstrated significant pharmacokinetic properties and efficacy against Mtb in a mouse TB infection model[1]. |
Alias | GSK656 HCl, GSK3036656 HCl |
Molecular Weight | 293.94 |
Formula | C10H14BCl2NO4 |
Cas No. | 2131798-13-3 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (170.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.