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GW 9578
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Catalog No. T27519Cas No. 247923-29-1
Alias GW-9578, GW9578
GW 9578 is a selective and potent PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.
GW 9578
😃Good
Catalog No. T27519Alias GW-9578, GW9578Cas No. 247923-29-1
GW 9578 is a selective and potent PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $75 | 35 days | |
| 1 mg | $140 | 35 days | |
| 5 mg | $563 | 35 days | |
| 10 mg | $980 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GW 9578 is a selective and potent PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes. |
| Targets&IC50 | PPARα (human):50 nM (EC50), PPARδ:2.6 (EC50s), PPARγ:1.5 (EC50), PPARα (mouse):5 nM (EC50), PPARα (murine):0.005 μM (EC50) |
| In vitro | GW9578 exhibits EC50 activities on Murine PPAR-α, PPAR-γ, and PPAR-δ at 0.005, 1.5, and 2.6 μM, respectively, and on Human PPAR-α, PPAR-γ, and PPAR-δ at 0.05, 1, and 1.4 μM, respectively [2]. In CD8+ T-cell line TK.1 cells, GW9578 (10 nM-1 μM, 24 hours) induces a dose-dependent increase in relative luciferase activity [3]. Conversely, in murine T-cell thymoma EL-4 T cells, GW9578 (10 nM-10 μM, 2 hours) significantly decreases IL-2 production compared to control cells [3]. |
| Alias | GW-9578, GW9578 |
| Molecular Weight | 492.62 |
| Formula | C26H34F2N2O3S |
| Cas No. | 247923-29-1 |
| Smiles | S(C(C(O)=O)(C)C)C1=CC=C(CCN(C(NC2=C(F)C=C(F)C=C2)=O)CCCCCCC)C=C1 |
| Relative Density. | 1.21 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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