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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 μg | $75 | 35 days | |
1 mg | $140 | 35 days | |
5 mg | $563 | 35 days | |
10 mg | $980 | 35 days |
Description | GW 9578 is a selective and potent PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes. |
In vitro | GW9578 exhibits activities on Murine PPAR-α, PPAR-γ, and PPAR-δ with EC50s of 0.005, 1.5, and 2.6 μM, respectively. Similarly, it shows activities on Human PPAR-α, PPAR-γ, and PPAR-δ with EC50s of 0.05, 1, and 1.4 μM, respectively[2].In the CD8+ T-cell line TK.1 cells, treatment with GW9578 (10 nM-1 μM for 24 hours) induces a dose-dependent increase in the amount of relative luciferase activity[3].On the other hand, treatment of murine T-cell thymoma EL-4 T cells with GW9578 (10 nM-10 μM for 2 hours) results in a significant decrease in IL-2 production compared to control cells[3]. |
Alias | GW9578, GW-9578 |
Molecular Weight | 492.62 |
Formula | C26H34F2N2O3S |
Cas No. | 247923-29-1 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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