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GW-803430

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GW-803430

Catalog No. T15450Cas No. 515141-51-2

GW-803430 is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH R1) (pIC50: 9.3). GW-803430 is orally active in an animal model of obesity.

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Pack Size	Price	Availability
25 mg	$970	8-10 weeks
50 mg	$1,260	8-10 weeks
100 mg	$1,910	8-10 weeks

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Product Introduction

Bioactivity

Description	GW-803430 is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH R1) (pIC50: 9.3). GW-803430 is orally active in an animal model of obesity.
Targets&IC50	MCH R1:(pic50)9.3
In vitro	GW-803430 shows a potent antagonist activity towards MCH induced MCHR1 receptor (IC50: ~13?nM)[2].
In vivo	GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t1/2=11 h) and brain penetration (6:1 brain: plasma concentration) in mice. GW-803430 (0.3, 3, and 15 mg/kg; p.o.; once daily) induces a sustained dose-dependent weight loss relative to vehicle controls [1].
Alias	GW-3430

Chemical Properties

Molecular Weight	481.99
Formula	C25H24ClN3O3S
Cas No.	515141-51-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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