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GW-803430
🥰Excellent
Catalog No. T15450Cas No. 515141-51-2
Alias GW803430A, GW803430, GW-3430, GW3430, GW 803430A
GW-803430 (GW-3430) is an orally active and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist used in the study of obesity.
GW-803430
🥰Excellent
Catalog No. T15450Alias GW803430A, GW803430, GW-3430, GW3430, GW 803430ACas No. 515141-51-2
GW-803430 (GW-3430) is an orally active and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist used in the study of obesity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 5 mg | $147 | In Stock | |
| 10 mg | $263 | In Stock | |
| 25 mg | $559 | In Stock | |
| 50 mg | $779 | In Stock | |
| 100 mg | $1,050 | In Stock | |
| 200 mg | $1,420 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $178 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GW-803430 (GW-3430) is an orally active and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist used in the study of obesity. |
| Targets&IC50 | MCHR1:13 nM |
| In vitro | GW-803430 exhibits significant antagonistic activity against the action of MCH on the MCHR1 receptor with an IC50 value of approximately 13 nM. [2] |
| In vivo | GW-803430 administered orally once daily at doses of 0.3, 3, and 15 mg/kg induced significant and sustained dose-dependent body weight loss compared to controls. GW-803430 has a favorable pharmacokinetic profile with a bioavailability of 31%, a half-life of 11 hours, and has been shown to exhibit excellent brain penetration in mice with a brain to plasma concentration ratio of 6:1, and is therefore considered an ideal compound. [1] |
| Alias | GW803430A, GW803430, GW-3430, GW3430, GW 803430A |
| Molecular Weight | 481.99 |
| Formula | C25H24ClN3O3S |
| Cas No. | 515141-51-2 |
| Smiles | O=C1C=2SC(=CC2N=CN1C3=CC=C(OCCN4CCCC4)C(OC)=C3)C=5C=CC(Cl)=CC5 |
| Relative Density. | 1.37 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (20.75 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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