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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $970 | 8-10 weeks | |
50 mg | $1,260 | 8-10 weeks | |
100 mg | $1,910 | 8-10 weeks |
Description | GW-803430 is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH R1) (pIC50: 9.3). GW-803430 is orally active in an animal model of obesity. |
Targets&IC50 | MCH R1:(pic50)9.3 |
In vitro | GW-803430 shows a potent antagonist activity towards MCH induced MCHR1 receptor (IC50: ~13?nM)[2]. |
In vivo | GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t1/2=11 h) and brain penetration (6:1 brain: plasma concentration) in mice. GW-803430 (0.3, 3, and 15 mg/kg; p.o.; once daily) induces a sustained dose-dependent weight loss relative to vehicle controls [1]. |
Alias | GW-3430 |
Molecular Weight | 481.99 |
Formula | C25H24ClN3O3S |
Cas No. | 515141-51-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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