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TC-MCH 7c

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Purity:98.8%

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COA HPLC HNMR

TC-MCH 7c

Catalog No. T13101Cas No. 864756-35-4

TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM.

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Pack Size	Price	Availability
1 mg	$95	In Stock
5 mg	$289	In Stock
10 mg	$415	In Stock
25 mg	$636	In Stock
50 mg	$858	In Stock
100 mg	$1,150	In Stock
500 mg	$2,310	In Stock
1 mL x 10 mM (in DMSO)	$261	In Stock

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Product Introduction

Bioactivity

Description	TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM.
In vitro	In [Ca2+]i mobilization, TC-MCH 7c has an IC50 of 9.7 μM for MCH1R [1]. TC-MCH 7c has IC50s of 23 nM and 9.0 μM for FLIPR and hERG, respectively[2].
In vivo	In DIO mice model, TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) shows excellent body weight reduction in a dose-dependent manner [1]. TC-MCH 7c(oral; 3 to 30mg /kg) and 30mg /kg at 2, 15 and 24 h were 5.1, 1.8 and 0.7 μM, respectively[2].

Chemical Properties

Molecular Weight	408.47
Formula	C24H25FN2O3
Cas No.	864756-35-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

1eq. HCl: 36.8 mg/mL (90.0 mM)

DMSO: 55 mg/mL (134.65 mM)

Solution Preparation Table

DMSO/1eq. HCl

	1mg	5mg	10mg	50mg
1 mM	2.4482 mL	12.2408 mL	24.4816 mL	122.4080 mL
5 mM	0.4896 mL	2.4482 mL	4.8963 mL	24.4816 mL
10 mM	0.2448 mL	1.2241 mL	2.4482 mL	12.2408 mL
20 mM	0.1224 mL	0.6120 mL	1.2241 mL	6.1204 mL
50 mM	0.0490 mL	0.2448 mL	0.4896 mL	2.4482 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0245 mL	0.1224 mL	0.2448 mL	1.2241 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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