Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

TC-MCH 7c

Catalog No. T13101Cas No. 864756-35-4

TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM.

TC-MCH 7c

TC-MCH 7c

Purity: 98.8%
Catalog No. T13101Cas No. 864756-35-4
TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM.
Pack SizePriceAvailabilityQuantity
1 mg$95In Stock
5 mg$289In Stock
10 mg$415In Stock
25 mg$636In Stock
50 mg$858In Stock
100 mg$1,150In Stock
500 mg$2,310In Stock
1 mL x 10 mM (in DMSO)$261In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "TC-MCH 7c"

Select Batch
Purity:98.8%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM.
Targets&IC50
MCH1R (mouse):3.0 nM , MCH1R (mouse):3.0 nM, MCH1R (human):5.6 nM, MCH1R (human):3.4 nM (ki), MCH1R (human):(ki)3.4 nM , MCH1R (human):5.6 nM
In vitro
In [Ca2+]i mobilization, TC-MCH 7c has an IC50 of 9.7 μM for MCH1R [1]. TC-MCH 7c has IC50s of 23 nM and 9.0 μM for FLIPR and hERG, respectively[2].
In vivo
In DIO mice model, TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) shows excellent body weight reduction in a dose-dependent manner [1]. TC-MCH 7c(oral; 3 to 30mg /kg) and 30mg /kg at 2, 15 and 24 h were 5.1, 1.8 and 0.7 μM, respectively[2].
Chemical Properties
Molecular Weight408.47
FormulaC24H25FN2O3
Cas No.864756-35-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
1eq. HCl: 36.8 mg/mL (90.0 mM)
DMSO: 55 mg/mL (134.65 mM), Sonication is recommended.
Solution Preparation Table
1eq. HCl/DMSO
1mg5mg10mg50mg
1 mM2.4482 mL12.2408 mL24.4816 mL122.4080 mL
5 mM0.4896 mL2.4482 mL4.8963 mL24.4816 mL
10 mM0.2448 mL1.2241 mL2.4482 mL12.2408 mL
20 mM0.1224 mL0.6120 mL1.2241 mL6.1204 mL
50 mM0.0490 mL0.2448 mL0.4896 mL2.4482 mL
DMSO
1mg5mg10mg50mg
100 mM0.0245 mL0.1224 mL0.2448 mL1.2241 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy TC-MCH 7c | purchase TC-MCH 7c | TC-MCH 7c cost | order TC-MCH 7c | TC-MCH 7c chemical structure | TC-MCH 7c in vivo | TC-MCH 7c in vitro | TC-MCH 7c formula | TC-MCH 7c molecular weight