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MCHR1 antagonist 2
🥰Excellent
Catalog No. T11966Cas No. 863115-70-2
MCHR1 antagonist 2 is an inhibitor of melanin-concentrating hormone receptor 1 (MCH1-R, IC50 = 65 nM) and also inhibits hERG.
MCHR1 antagonist 2
🥰Excellent
Purity: 97.16%
Catalog No. T11966Cas No. 863115-70-2
MCHR1 antagonist 2 is an inhibitor of melanin-concentrating hormone receptor 1 (MCH1-R, IC50 = 65 nM) and also inhibits hERG.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $45 | In Stock | |
| 5 mg | $106 | In Stock | |
| 10 mg | $179 | In Stock | |
| 25 mg | $388 | In Stock | |
| 50 mg | $619 | In Stock | |
| 100 mg | $993 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $128 | In Stock |
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Purity:97.16%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MCHR1 antagonist 2 is an inhibitor of melanin-concentrating hormone receptor 1 (MCH1-R, IC50 = 65 nM) and also inhibits hERG. |
| Targets&IC50 | Ca2+ flux:196 ± 30 nM((IMR-32 cells)), MCH1R:65 nM , ERG (human):4.0 nM(IMR-32 cells) |
| In vitro | MCHR1 antagonist 2 has inhibitory effects on Ca2+ flux, and hERG, with IC50s of 196 ± 30 nM and 4.0 ± 0.8 nM, respectively, in IMR-32 cells.MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM. |
| Molecular Weight | 424.42 |
| Formula | C23H21FN2O5 |
| Cas No. | 863115-70-2 |
| Smiles | Fc1ccc2oc(cc(=O)c2c1)C(=O)NC1CCN(Cc2ccc3OCOc3c2)CC1 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (21.21 mM), when pH is adjusted to 6 with HCl. Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
Potassium ChannelMelaninconcentratingHormoneReceptor(MCHR)MelaninconcentratingHormoneReceptorMelaninconcentrating Hormone Receptor (MCHR)Melanin-concentrating Hormone ReceptorMelanin concentrating hormone receptor 1melanin concentrating hormone receptor 1melaninMCHR-1 antagonist 2MCHR1 antagonist 2MCHR1 (GPR24)MCHRMCH1-RKcsAInhibitorinhibitIMR-32hormonehERG in IMR-32 cellshERGconcentrating
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