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hAChE-IN-3
hAChE-IN-3
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hAChE-IN-3
Catalog No. T79299
hAChE-IN-3 (compound 5c) serves as a potent inhibitor for AChE, BuChE, MAO-B, and BACE-1, with respective IC50 values of 0.44, 0.08, 5.15, and 0.38 μM, demonstrating its ability to cross the blood-brain barrier. This compound also exhibits antioxidant properties and metal chelation capabilities. Additionally, it targets peripheral anion sites, potentially modulating β-amyloid and ameliorating neurodegeneration linked to Alzheimer's disease, highlighting its research potential for this condition [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | hAChE-IN-3 (compound 5c) serves as a potent inhibitor for AChE, BuChE, MAO-B, and BACE-1, with respective IC50 values of 0.44, 0.08, 5.15, and 0.38 μM, demonstrating its ability to cross the blood-brain barrier. This compound also exhibits antioxidant properties and metal chelation capabilities. Additionally, it targets peripheral anion sites, potentially modulating β-amyloid and ameliorating neurodegeneration linked to Alzheimer's disease, highlighting its research potential for this condition [1]. |
| Targets&IC50 | BChE:0.08 μM, AChE:0.44 μM, MAO-B:5.15 μM |
| In vitro | hAChE-IN-3 (compound 5c) exhibits an IC50 of 36.28 μM in the SH-SY5Y cell line after 24 hours and an IC50 of 154.10 μM in the HepG2 cell line after 48 hours [1]. Additionally, hAChE-IN-3 demonstrates an IC50 of 2.58 μM against β-amyloid plaque aggregation with an inhibition rate of 59% at 10 μM [1]. |
| Molecular Weight | 541.98 |
| Formula | C30H24ClN3O5 |
| Cas No. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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