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Heparan Sulfate

Catalog No. T19355Cas No. 9050-30-0

Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG) that is tightly attached to cell surface or extracellular matrix proteins.

Heparan Sulfate

Heparan Sulfate

Catalog No. T19355Cas No. 9050-30-0
Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG) that is tightly attached to cell surface or extracellular matrix proteins.
Pack SizePriceAvailabilityQuantity
1 mg$44In Stock
5 mg$97In Stock
10 mg$163In Stock
25 mg$322In Stock
50 mg$538In Stock
100 mg$777In Stock
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Potency:58.0IU/mg
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Product Introduction

Bioactivity
Description
Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG) that is tightly attached to cell surface or extracellular matrix proteins.
In vitro
METHODS: Breast cancer cells MDA-MB231 were treated with Heparan sulfate (20 µg/mL) for 24 h and detected by Fluorescence microscopy.
RESULTS: Cell spreading was enhanced and the average spreading cell area approximately doubled in the presence of Heparan sulfate. Exogenous Heparan sulfate blocked cell invasion and matrix degradation. [1]
In vivo
METHODS: To assay anti-tumor activity in vivo, Heparan sulfate (0.8 mg/kg) was administered to SCID-hu mice injected with bone marrow aspirates from myeloma patients twice daily, once intraperitoneally and once subcutaneously, for four weeks.
RESULTS: Treatment with Heparan sulfate significantly inhibited primary tumor growth in a human severe combined immunodeficiency (SCID-hu) myeloma model. [2]
Chemical Properties
Molecular Weight593.47(monomer)
FormulaC12H19NO20S3 (monomer)
Cas No.9050-30-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: Insoluble
H2O: 100 mg/mL (168.50 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mMNaN mLNaN mLNaN mLNaN mL
5 mMNaN mLNaN mLNaN mLNaN mL
10 mMNaN mLNaN mLNaN mLNaN mL
20 mMNaN mLNaN mLNaN mLNaN mL
50 mMNaN mLNaN mLNaN mLNaN mL
100 mMNaN mLNaN mLNaN mLNaN mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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