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Hibifolin

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Purity:98.13%

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COA HPLC HNMR

Hibifolin

Catalog No. TN1736Cas No. 55366-56-8

Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity.

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Pack Size	Price	Availability
1 mg	$54	In Stock
5 mg	$122	In Stock
10 mg	$178	In Stock
25 mg	$297	In Stock
50 mg	$453	In Stock
100 mg	$655	In Stock

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Product Introduction

Bioactivity

Description

Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity.

In vitro

the inhibitory activity of a plant flavonoid, hibifolin on ADA is investigated using enzyme kinetic assay and isothermal titration calorimetry.?The inhibitory constant of hibifolin was found to be 49.92μM 3.98 and the mode of binding was reversible.?Isothermal titration calorimetry showed that the compound binds ADA with binding energy of -7.21Kcal/mol.?The in silico modeling and docking studies showed that the bound ligand is stabilized by hydrogen bonds with active site residues of the enzyme.?hibifolin can act as a potential inhibitor of ADA.

Chemical Properties

Molecular Weight	494.36
Formula	C21H18O14
Cas No.	55366-56-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (111.25 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0228 mL	10.1141 mL	20.2282 mL	101.1409 mL
5 mM	0.4046 mL	2.0228 mL	4.0456 mL	20.2282 mL
10 mM	0.2023 mL	1.0114 mL	2.0228 mL	10.1141 mL
20 mM	0.1011 mL	0.5057 mL	1.0114 mL	5.0570 mL
50 mM	0.0405 mL	0.2023 mL	0.4046 mL	2.0228 mL
100 mM	0.0202 mL	0.1011 mL	0.2023 mL	1.0114 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc