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Hyperforin
🥰Excellent
Catalog No. TN1755Cas No. 11079-53-1
Hyperforin, a natural product from Hypericum, is commonly used as an antidepressant and also has neurological, inflammatory, antimicrobial, antitumor and antiangiogenic effects. Hyperforin acts as a monoamine reuptake inhibitor (MRI) in vitro, including serotonin, norepinephrine, dopamine, GABA, and glutamate, with an IC 50 of ≈0.1 μg/mL. Hyperforin is also capable of inducing the cytochrome P450 enzymes, CYP3A4 and CYP2C9, through binding to and activation of the pregnane X receptor. Hyperforin is capable of activating TRPC6 channels by binding to a specific motif.
Hyperforin
🥰Excellent
Catalog No. TN1755Cas No. 11079-53-1
Hyperforin, a natural product from Hypericum, is commonly used as an antidepressant and also has neurological, inflammatory, antimicrobial, antitumor and antiangiogenic effects. Hyperforin acts as a monoamine reuptake inhibitor (MRI) in vitro, including serotonin, norepinephrine, dopamine, GABA, and glutamate, with an IC 50 of ≈0.1 μg/mL. Hyperforin is also capable of inducing the cytochrome P450 enzymes, CYP3A4 and CYP2C9, through binding to and activation of the pregnane X receptor. Hyperforin is capable of activating TRPC6 channels by binding to a specific motif.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $400 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Hyperforin, a natural product from Hypericum, is commonly used as an antidepressant and also has neurological, inflammatory, antimicrobial, antitumor and antiangiogenic effects. Hyperforin acts as a monoamine reuptake inhibitor (MRI) in vitro, including serotonin, norepinephrine, dopamine, GABA, and glutamate, with an IC 50 of ≈0.1 μg/mL. Hyperforin is also capable of inducing the cytochrome P450 enzymes, CYP3A4 and CYP2C9, through binding to and activation of the pregnane X receptor. Hyperforin is capable of activating TRPC6 channels by binding to a specific motif. |
| In vitro | Methods: Hyperforin (0.1, 1, 10 μM) was used to treat TNF α-stimulated HaCaT cells, and the expression of related proteins was determined by Western Blot. Results: Hyperforin at a dose of 10 μM reduced the expression of p-p38, p-ERK, p-JNK, and p-STAT3 in HaCaT cells. [3] |
| In vivo | Methods: Hyperforin (5 mg/kg, once a day, 7 days) was used to treat IMQ-induced psoriasis-like mouse models to observe whether it improved the skin lesions of psoriasis. Results: Hyperforin significantly improved skin lesions throughout the treatment period, while inhibiting the infiltration of CD3+ T cells and downregulating the expression of Il1, Il6, Il23, Il17a, Il22, and antimicrobial peptides (AMPs) in skin lesions. [3] |
| Molecular Weight | 536.79 |
| Formula | C35H52O4 |
| Cas No. | 11079-53-1 |
| Smiles | C(C(C)C)(=O)[C@@]12[C@@](CCC=C(C)C)(C)[C@@H](CC=C(C)C)C[C@@](CC=C(C)C)(C1=O)C(=O)C(CC=C(C)C)=C2O |
| Relative Density. | 1.010 g/cm3 at 20℃ |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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