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Hyperforin

Catalog No. TN1755 CAS 11079-53-1

Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts.

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Hyperforin, CAS 11079-53-1

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Purity: 98%

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Description

Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts.

In vitro

We demonstrate that the phloroglucinol derivative Hyperforin is not only the major lipophilic chemical constituent of the medicinal plant Hypericum perforatum (St. John's wort) but also a potent uptake inhibitor of serotonin (5-HT), dopamine (DA), noradrenaline (NA), GABA and L-Glutamate with IC50 values of about 0.05-0.10 microg/ml (5-HT, NA, DA, GABA) and about 0.5 microg/ml (L-glutamate) in synaptosomal preparations. Furthermore, potencies of two different hypericum extracts in two conventional pharmacological paradigms useful for the detection of antidepressants (behavioral despair, learned helplessness), closely correlate with their Hyperforin contents. In addition, most till now known neuropharmacological properties of the clinically used hypericum extracts can also be demonstrated with pure Hyperforin.

Molecular Weight	536.79
Formula	C35H52O4
CAS No.	11079-53-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hyperforin as a possible antidepressant component of hypericum extracts.Life Sci. 1998;63(6):499-510.

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Keywords

Hyperforin 11079-53-1 GPCR/G Protein Immunology/Inflammation Neuroscience 5-HT Receptor COX Inhibitor inhibitor inhibit

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