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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $32 | 7-10 days | |
25 mg | $49 | 7-10 days | |
50 mg | $91 | 7-10 days | |
1 mL x 10 mM (in DMSO) | $119 | 7-10 days |
Description | I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis. |
In vitro | In vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. |
In vivo | In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, the survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05). |
Molecular Weight | 443.58 |
Formula | C25H37N3O4 |
Cas No. | 331963-29-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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