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IMB-808
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Catalog No. T25528Cas No. 870768-70-0
Alias IMB808
IMB-808 is an LXRα/β dual agonist that promotes ABCA1 expression and cholesterol efflux without inducing lipidogenesis in HepG2 cells. IMB-808 can be used in atherosclerosis research.
IMB-808
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Catalog No. T25528Alias IMB808Cas No. 870768-70-0
IMB-808 is an LXRα/β dual agonist that promotes ABCA1 expression and cholesterol efflux without inducing lipidogenesis in HepG2 cells. IMB-808 can be used in atherosclerosis research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $50 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | IMB-808 is an LXRα/β dual agonist that promotes ABCA1 expression and cholesterol efflux without inducing lipidogenesis in HepG2 cells. IMB-808 can be used in atherosclerosis research. |
| Targets&IC50 | LXRβ:0.53 μM (EC50), LXRα:0.15 μM (EC50) |
| In vitro | IMB-808 exhibited a significant dose-dependent effect in the concentration range of 0.001 μM to 30 μM by activating LXRβ with an EC50 of 0.53 μM. In addition, IMB-808 was able to activate LXRα in a dose-dependent manner in a luciferase reporter gene assay with the GAL4-pGL4-luc reporter plasmid with an EC50 of 0.15 μM. M.[1] IMB-808 (0 μM-10 μM; 18 hours) significantly increased the protein and mRNA levels of ABCG1 and ABCA1 in RAW264.7 macrophage. [1] IMB-808 (0.1 μM-10 μM; 24 h) enhanced cholesterol efflux capacity in a dose-dependent manner while decreasing cellular cholesterol concentration in cell lines. [1] |
| Alias | IMB808 |
| Molecular Weight | 380.32 |
| Formula | C18H15F3N2O4 |
| Cas No. | 870768-70-0 |
| Smiles | O=C(C1=CC=C2OCCOC2=C1)N(C)CC(=O)NC3=CC=C(F)C(F)=C3F |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 200 mg/mL (525.87 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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