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IRAK4-IN-27
Catalog No. T79485
IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor with an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line, making it a valuable agent for DLBCL research [1].
IRAK4-IN-27
IRAK4-IN-27
Catalog No. T79485
IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor with an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line, making it a valuable agent for DLBCL research [1].
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| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor with an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line, making it a valuable agent for DLBCL research [1]. |
| Targets&IC50 | IRAK4:8.7 nM |
| In vitro | IRAK4-IN-27 (Compound 22, 72 h) exhibited antiproliferative activity in MYD88 L265P DLBCL cell lines (OCI-LY10, IC50 = 0.248 μM) and MYD88 wild-type cell lines (U2932, IC50 = 1.251 μM; GM00637, IC50 = 1.520 μM). IRAK4-IN-27 (0.5 μM and 1 μM, for 24 and 48 h) induced apoptosis in OCI-LY10 cells and, at concentrations of 0.03-3 μM, inhibited IRAK4 phosphorylation and associated signaling pathways. Furthermore, IRAK4-IN-27 (0.1 μM and 0.2 μM, 48 h) in combination with Ibrutinib suppressed OCI-LY10 cell growth and induced apoptosis. [1] |
| Molecular Weight | 430.46 |
| Formula | C23H22N6O3 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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