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IRES-C11

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Catalog No. T40419Cas No. 342416-30-2
Alias IRES-C11

IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.

IRES-C11

IRES-C11

🥰Excellent
Catalog No. T40419Alias IRES-C11Cas No. 342416-30-2
IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.
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Product Introduction

Bioactivity
Description
IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.
In vitro
IRES-C11 (50 nM) significantly inhibits both cyclin D1 and c-MYC IRES activity. IRES-C11 treatment induces a significant shift in both cyclin D1 and c-MYC mRNA to monosomal/nonribosomal fractions, whereas actin mRNA distribution is unaffected. IRES-C11 inhibits both cyclin D1 and c-MYC IRES-mediated mRNA translation, leading to reductions in protein levels. Mechanistic studies with IRES-C11 reveal the binding of the inhibitors within the UP1 fragment of heterogeneous nuclear ribonucleoprotein A1.[1]
AliasIRES-C11
Chemical Properties
Molecular Weight316.14
FormulaC13H11Cl2NO4
Cas No.342416-30-2
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 225.0 mg/mL (711.7 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1632 mL15.8158 mL31.6316 mL158.1578 mL
5 mM0.6326 mL3.1632 mL6.3263 mL31.6316 mL
10 mM0.3163 mL1.5816 mL3.1632 mL15.8158 mL
20 mM0.1582 mL0.7908 mL1.5816 mL7.9079 mL
50 mM0.0633 mL0.3163 mL0.6326 mL3.1632 mL
100 mM0.0316 mL0.1582 mL0.3163 mL1.5816 mL

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