Shopping Cart
- Remove All
- Your shopping cart is currently empty
IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $148 | In Stock | |
5 mg | $373 | In Stock | |
10 mg | $683 | In Stock | |
25 mg | $1,330 | In Stock | |
50 mg | $1,750 | In Stock | |
100 mg | $2,690 | In Stock | |
1 mL x 10 mM (in DMSO) | $388 | In Stock |
Description | IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53. |
In vitro | IRES-C11 (50 nM) significantly inhibits both cyclin D1 and c-MYC IRES activity. IRES-C11 treatment induces a significant shift in both cyclin D1 and c-MYC mRNA to monosomal/nonribosomal fractions, whereas actin mRNA distribution is unaffected. IRES-C11 inhibits both cyclin D1 and c-MYC IRES-mediated mRNA translation, leading to reductions in protein levels. Mechanistic studies with IRES-C11 reveal the binding of the inhibitors within the UP1 fragment of heterogeneous nuclear ribonucleoprotein A1.[1] |
Alias | IRES-C11 |
Molecular Weight | 316.14 |
Formula | C13H11Cl2NO4 |
Cas No. | 342416-30-2 |
Smiles | COc1ccc(CN2C(=O)C(Cl)=C(Cl)C2=O)c(OC)c1 |
Relative Density. | no data available |
Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 225.0 mg/mL (711.7 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.