Shopping Cart
- Remove All
Your shopping cart is currently empty
10074-A4
🥰Excellent
Catalog No. T9628Cas No. 312631-87-1
10074-A4 is a c-Myc binding compound that associates with c-Myc[370–409] and acts as a “ligand cloud” around a “protein cloud”, exhibiting distinct characteristics compared to a non-binding ligand.
10074-A4
🥰Excellent
Purity: 98.01%
Catalog No. T9628Cas No. 312631-87-1
10074-A4 is a c-Myc binding compound that associates with c-Myc[370–409] and acts as a “ligand cloud” around a “protein cloud”, exhibiting distinct characteristics compared to a non-binding ligand.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $65 | In Stock | |
| 5 mg | $137 | In Stock | |
| 10 mg | $208 | In Stock | |
| 25 mg | $353 | In Stock | |
| 50 mg | $505 | In Stock | |
| 100 mg | $696 | In Stock | |
| 200 mg | $938 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $158 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "10074-A4"
Nicotinamide N-oxide
Nicotinamide-N-oxide, Nicotinamide 1-oxide, 1-oxynicotinamide
T06171986-81-8
Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase.
- $33
Size
QTY
VPC-70063
Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-
T6001913571-44-3
VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.
- $47
Size
QTY
MYCi975
NUCC-0200975
T121332289691-01-4
MYCi975 (NUCC-0200975) is an orally active MYC inhibitor.
- $127
Size
QTY
10058-F4
Cited
c-Myc Inhibitor
T3048403811-55-2
10058-F4 (c-Myc Inhibitor) is a cell-permeable thiazolidinone that specifically inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression; induces cell-cycle arrest and apoptosis.
- $43
Size
QTY
CitedBTYNB
MDK6620, BTYNB IMP1 Inhibitor
T9033304456-62-0
BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB). It disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association
- $40
Size
QTY
Mycro 3
Mycro-3
T4367944547-46-0
Mycro 3 is potent and selective for c-Myc in whole cell assays.
- $45
Size
QTY
MYCMI-6
NSC354961
T12134681282-09-7
MYCMI-6 (NSC-354961) is a potent and selective inhibitor of endogenous MYC:MAX protein interactions，reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects.
- $68
Size
QTY
ML327
T42521883510-31-3
ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).
- $45
Size
QTY
APTO-253
LT-253, LOR-253
T10352916151-99-0
APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through the induction of the KLF4 tumor suppressor.
- $36
Size
QTY
Select Batch
Purity:98.01%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 10074-A4 is a c-Myc binding compound that associates with c-Myc[370–409] and acts as a “ligand cloud” around a “protein cloud”, exhibiting distinct characteristics compared to a non-binding ligand. |
| Targets&IC50 | c-Myc:15.1 ± 2.3 μM(EC50), c-Myc:36.3 ± 9.0 μM(Kd) |
| In vitro | 10074-A4 showed binding affinity with c-Myc370–409 with Kd of 36.3?±?9.0?μM and EC50 of 15.1?±?2.3?μM[2].10074-A4 arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells[2]. |
| Molecular Weight | 409.29 |
| Formula | C18H14Cl2N2O3S |
| Cas No. | 312631-87-1 |
| Smiles | OC(CN1C(=O)CSC1=O)Cn1c2ccc(Cl)cc2c2cc(Cl)ccc12 |
| Relative Density. | No data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (244.33 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy 10074-A4 | purchase 10074-A4 | 10074-A4 cost | order 10074-A4 | 10074-A4 chemical structure | 10074-A4 in vitro | 10074-A4 formula | 10074-A4 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.