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MYCi975
🥰Excellent
Catalog No. T12133Cas No. 2289691-01-4
Alias NUCC-0200975
MYCi975 (NUCC-0200975) is an orally active MYC inhibitor.
MYCi975
🥰Excellent
Purity: 99.58%
Catalog No. T12133Alias NUCC-0200975Cas No. 2289691-01-4
MYCi975 (NUCC-0200975) is an orally active MYC inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $127 | In Stock | |
| 5 mg | $297 | In Stock | |
| 10 mg | $492 | In Stock | |
| 25 mg | $819 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $383 | In Stock |
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Purity:99.58%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | MYCi975 (NUCC-0200975) is an orally active MYC inhibitor. |
| In vitro | MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner(IC50s of 3.7, 3.9, 6.4 μM, respectively)[1]. |
| In vivo | The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index. An improved analog, MYCi975 showed better tolerability. |
| Alias | NUCC-0200975 |
| Molecular Weight | 561.3 |
| Formula | C25H16Cl2F6N2O2 |
| Cas No. | 2289691-01-4 |
| Smiles | O(CC1=CC=C(Cl)C=C1)C2=C(C(O)=C(C=C2)C3=CC(C(F)(F)F)=NN3C)C4=CC(C(F)(F)F)=C(Cl)C=C4 |
| Relative Density. | 1.45 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 247 mg/mL (440.05 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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