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KU-32
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KU-32
Catalog No. T15671Cas No. 956498-70-7
KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $10,568 | 10-14 weeks | |
| 50 mg | $13,728 | 10-14 weeks | |
| 100 mg | $17,839 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death. |
| In vitro | KU-32 protects against glucose-induced death of embryonic DRG (dorsal root ganglia) neurons cultured for 3 days in vitro. Treating human islets with KU-32 for 24 hours displays no toxicity. KU-32 improves cellular viability by blocking apoptosis, with a minimum of 2-day exposure. When preincubate in KU-32, isolated human islets release more glucose-stimulated insulin [1] [2]. |
| In vivo | Administered with KU-32 (10 weeks; diabetic BKS-db/db mice) do not display any obvious changes in blood glucose and insulin levels, despite having greater insulin staining/beta cells in the pancreas compared to untreated BKS db/db mice[1]. |
| Molecular Weight | 407.41 |
| Formula | C20H25NO8 |
| Cas No. | 956498-70-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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