Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $231 | In Stock | |
5 mg | $398 | In Stock | |
10 mg | $592 | In Stock | |
25 mg | $947 | In Stock | |
50 mg | $1,280 | In Stock | |
100 mg | $1,730 | In Stock | |
500 mg | $3,470 | In Stock |
Description | KY-02327, a metabolically stabilized analog of KY-02061, serves as a potent inhibitor of the Dishevelled (Dvl)-CXXC5 interaction. This compound activates the Wnt/β-catenin pathway, thereby promoting osteoblast differentiation. |
In vitro | KY-02327 treatment (1-10 μM; 2 days) on MC3T3E1 cells, a murine pre-osteoblast cell line, enhances β-catenin protein level and Runx2, as well as nuclear β-catenin accumulation, in a dose-dependent manner [1]. Additionally, KY-02327 (1-10 μM) elevates the mRNA expression of osteoblast differentiation markers, collagen 1a (Col1a) and osteocalcin (OCN) [1]. |
In vivo | KY-02327 (20 mg/kg; p.o.; administered for 5 consecutive days each week for 4 weeks) effectively mitigates bone loss in an ovariectomized (OVX) mouse model, demonstrating its potential for osteoporosis treatment by stimulating bone growth[1]. In this study, 8-week-old female BL6 mice were treated following the specified regimen, resulting in increased bone formation in the femur, confirmed by calcein labeling, compared to vehicle-treated OVX mice. |
Molecular Weight | 373.45 |
Formula | C20H27N3O4 |
Cas No. | 2093407-25-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (267.77 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.