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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $78 | 35 days | |
5 mg | $250 | 35 days | |
10 mg | $348 | 35 days | |
25 mg | $595 | 35 days |
Description | L-2-Hydroxyglutaric acid, an epigenetic modifier and potential oncometabolite in renal cancer, impedes mitochondrial creatine kinase (Mi-CK) activity, exhibiting Km and Ki values of 2.52 mM and 11.13 mM, respectively. Additionally, it obstructs histone demethylases, thereby encouraging histone methylation. |
In vitro | L-2-Hydroxyglutaric acid effectively inhibits 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs), such as the Ten Eleven Translocation (TET) enzymes. |
Alias | (S)-2-Hydroxyglutaric acid |
Molecular Weight | 148.11 |
Formula | C5H8O5 |
Cas No. | 13095-48-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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