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L-902688
Catalog No. T15690Cas No. 634193-54-7
L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid receptors.
L-902688
Catalog No. T15690Cas No. 634193-54-7
L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid receptors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $280 | 35 days | |
| 1 mg | $530 | 35 days | |
| 5 mg | $2,360 | 35 days | |
| 10 mg | $4,170 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid receptors. |
| Targets&IC50 | EP4:0.38 nM (ki), EP4:0.6 nM (EC50) |
| In vitro | L-902688 (1 μM; 24 hours; HUVE cells) treatment, decreases TGF-β-induced Twist and α-smooth muscle actin (α-SMA) expression. |
| In vivo | In the monocrotaline (MCT)-induced PAH rat model, L-902688 (0.25-1 μg/kg/day; intraperitoneal injection; daily; for 3 weeks; adult male Sprague-Dawley rats) treatment decreases right ventricle fibrosis [1]. |
| Molecular Weight | 419.47 |
| Formula | C21H27F2N5O2 |
| Cas No. | 634193-54-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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